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Recombinant Human Phosphoglycerate Mutase 1 (Brain), His-tagged

Cat. No.: PGAM1-2786H
Product Overview: Recombinant human PGAM protein (1-254aa), fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Description: PGAM1 belongs to the phosphoglycerate mutase family. This protein is important components of glucose and 2,3-BPGA (2,3-bisphosphoglycerate) metabolism and catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). Mutations in this protein cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.
Source: E.coli.
Sequences: MGSSHHHHHH SSGLVPRGSH MAAYKLVLIR HGESAWNLEN RFSGWYDADL SPAGHEEAKR GGQALRDAGY EFDICFTSVQ KRAIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSCESLKDTI ARALPFWNEE IVPQIKEGKR VLIAAHGNSL RGIVKHLEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVR KAMEAVAAQG KAKK.
Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1M Nacl, 1mM DTT, 10% glycerol.
Molecular Weight: 30.9kDa (274aa), confirmed by MALDI-TOF.
Purity: > 90% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PGAM1 phosphoglycerate mutase 1 (brain) [ Homo sapiens ]
Synonyms:
PGAM1; phosphoglycerate mutase 1 (brain); BPG-dependent PGAM 1; phosphoglycerate mutase 1; phosphoglycerate mutase A, nonmuscle form; phosphoglycerate mutase isozyme B; EC 3.1.3.13; EC 5.4.2.1; EC 5.4.2.4
Gene ID: 5223
mRNA Refseq: NM_002629
Protein Refseq: NP_002620
MIM: 172250
UniProt ID: P18669
Chromosome Location: 10q25.3
Pathway: Glycolysis / Gluconeogenesis; Metabolic pathways
Function: 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity;bisphosphoglycerate mutase activity;hydrolase activity;isomerase activity;phosphoglycerate mutase activity; protein kinase binding

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