Recombinant Human ACMSD Protein, MYC/DDK-tagged

• Cat.No.: ACMSD-910H
• Product Overview: Recombinant human ACMSD protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Description: The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004].
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 37.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: aminocarboxymuconate semialdehyde decarboxylase[ Homo sapiens ]
• Official Symbol: ACMSD
• Synonyms: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; OTTHUMP00000162500; aminocarboxymuconate semialdehyde decarboxylase
• Gene ID: 130013
• mRNA Refseq: NM_138326.2
• Protein Refseq: NP_612199
• MIM: 608889
• UniProt ID: Q8TDX5