Recombinant Mouse Acmsd Protein, Myc/DDK-tagged

• Cat.No.: Acmsd-1497M
• Product Overview: Purified recombinant protein of mouse full-length amino carboxymuconate semialdehyde decarboxylase (Acmsd), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
• Molecular Mass: 38.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Acmsd amino carboxymuconate semialdehyde decarboxylase [ Mus musculus (house mouse) ]
• Official Symbol: Acmsd
• Synonyms: ACMSD; amino carboxymuconate semialdehyde decarboxylase; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase
• Gene ID: 266645
• mRNA Refseq: NM_001033041
• Protein Refseq: NP_001028213
• UniProt ID: Q8R519