Recombinant Human CDK12/CCNK Protein (Q696-S1082/M1-S300), GST/Flag-tagged
| Cat.No. : | CDK12/CCNK-1661H |
| Product Overview : | Recombinant Human GST-TEV-CDK12(Q696-S1082)/pFastBac1-FLAG-TEV-Cyclink(1-300) protein with a GST/Flag was expressed in Insect cell |
- Specification
- Gene Information
- Related Products
| Description : | Cyclin-dependent kinase 12, Cdc2-related kinase, arginine/serine-rich, CrkRS, Cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, Cell division protein kinase 12, hCDK12; Cyclin-K Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). |
| Source : | Insect cell |
| Species : | Human |
| Tag : | GST/Flag |
| Form : | Liquid |
| Protein Length : | Q696-S1082/M1-S300 |
| Endotoxin : | < 0.01 EU/μg of the protein |
| Purity : | 90% |
| Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade |
| Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH 8.0), 200 mM NaCl, 5% glycerol. |
| Shipping : | It is shipped out with blue ice. |
| Gene Name : | CDK12 cyclin-dependent kinase 12 [ Homo sapiens (human) ] |
| Official Symbol : | CDK12 |
| Synonyms : | Cyclin-dependent kinase 12; Cdc2-related kinase; arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCDK12; Cyclin-K |
| Gene ID : | 51755 |
| mRNA Refseq : | NM_015083 |
| Protein Refseq : | NP_055898 |
| MIM : | 615514 |
| UniProt ID : | Q9NYV4 |
Products Types
| ◆ Recombinant Protein | ||
| CDK12/CCNK-1660H | Recombinant Human CDK12/CCNK Protein (Q696-S1082/M1-S300) | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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