| Description : |
Cyclin-dependent kinase 3, Cell division protein kinase 3; G1/S-specific cyclin-E1 Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. Essential for the control of the cell cycle at the G1/S (start) transition. |
| Source : |
Insect cell |
| Species : |
Human |
| Tag : |
Tag Free |
| Form : |
Liquid |
| Protein Length : |
M1-H305/M1-E410 |
| Endotoxin : |
< 0.01 EU/μg of the protein |
| Purity : |
90% |
| Stability : |
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade |
| Storage : |
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : |
Supplied as sterile 50 mM Tris-HCl (pH 7.5), 200 mM NaCl, 20% glycerol |
| Shipping : |
It is shipped out with blue ice. |
