Recombinant Human CHN1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CHN1-3758H
• Product Overview: CHN1 MS Standard C13 and N15-labeled recombinant protein (NP_001813) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 53 kDa
• AA Sequence: MALTLFDTDEYRPPVWKSYLYQLQQ EAPHPRRITCTCEVENRPKYYGREF HGMISREAADQLLIVAEGSYLIRES QRQPGTYTLALRFGSQTRNFRLYYD GKHFVGEKRFESIHDLVTDGLITLY IETKAAEYIAKMTINPIYEHVGYTT LNREPAYKKHMPVLKETHDERDSTG QDGVSEKRLTSLVRRATLKENEQIP KYEKIHNFKVHTFRGPHWCEYCANF MWGLIAQGVKCADCGLNVHKQCSKM VPNDCKPDLKHVKKVYSCDLTTLVK AHTTKRPMVVDMCIREIESRGLNSE GLYRVSGFSDLIEDVKMAFDRDGEK ADISVNMYEDINIITGALKLYFRDL PIPLITYDAYPKFIESAKIMDPDEQ LETLHEALKLLPPAHCETLRYLMAH LKRVTLHEKENLMNAENLGIVFGPT LMRSPELDAMAALNDIRYQRLVVEL LIKNEDILFTRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CHN1 chimerin 1 [ Homo sapiens (human) ]
• Official Symbol: CHN1
• Synonyms: CHN1; chimerin (chimaerin) 1; CHN, Duane retraction syndrome 2, DURS2; N-chimaerin; ARHGAP2; Chimerin 1 (GTPase activating protein; rho; 2); n chimerin; RhoGAP2; n-chimerin; A-chimaerin; a2-chimaerin; alpha-chimerin; Rho GTPase-activating protein 2; NC; CHN; DURS2; RHOGAP2
• Gene ID: 1123
• mRNA Refseq: NM_001822
• Protein Refseq: NP_001813
• MIM: 118423
• UniProt ID: P15882