CHN1 Protein

CHN1

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CHN1

Official Full Name chimerin (chimaerin) 1
Background This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duanes retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms CHN1; chimerin (chimaerin) 1; CHN, Duane retraction syndrome 2 , DURS2; N-chimaerin; ARHGAP2; Chimerin 1 (GTPase activating protein; rho; 2); n chimerin; RhoGAP2; A-chimaerin; Alpha-chimerin; CHIN_HUMAN; CHN; N chimaerin; N-chimerin; NC; Rho GTPase-activating protein 2; a2-chimaerin; OTTHUMP00000205333; OTTHUMP00000205334; OTTHUMP00000205335; OTTHUMP00000205339; OTTHUMP00000205340; OTTHUMP00000205342; DURS2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CHN1-3093H Recombinant Human CHN1 protein, His-tagged E.coli His
    Human CHN1-001HCL Recombinant Human CHN1 cell lysate Insect Cell N/A
    Human CHN1-002HCL Recombinant Human CHN1 cell lysate Insect Cell N/A
    Human CHN1-11192H Recombinant Human CHN1, GST-tagged E.coli GST
    Human CHN1-1256H Recombinant Human CHN1 Protein, GST-Tagged Wheat Germ GST
    Human CHN1-240H Recombinant Human CHN1, Gly&Pro tagged Insect Cell Fc
    Human CHN1-241H Recombinant Human CHN1, His-GST tagged Insect Cell Fc
    Human CHN1-3230H Recombinant Human CHN1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CHN1-3758H Recombinant Human CHN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Chn1-383M Recombinant Mouse Chn1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CHN1-1378R Recombinant Rat CHN1 Protein Mammalian Cell His
    Chicken CHN1-2163C Recombinant Chicken CHN1 Mammalian Cell His
    Zebrafish CHN1-12244Z Recombinant Zebrafish CHN1 Mammalian Cell His

    CHN1 involved in several pathways and played different roles in them. We selected most pathways CHN1 participated on our site, such as Regulation of RAC1 activity, Rho GTPase cycle, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of RAC1 activity CHN2; CHN1; ARHGAP9; SPATA13; RALBP1; ARHGAP1; RAP1GDS1; EPS8; ARHGEF25; DEF6
    Rho GTPase cycle ABR; ARHGAP4; ARHGAP33; OPHN1; OBSCN; CHN1; TAGAPB; ARHGEF3; ARHGEF16; RHOUA
    Signal Transduction PENKB; DNER; GAS8; CXCR7B; PRC1B; INSL3; FGD2; SPOP; OR52J3; PDK2B
    Signaling by Rho GTPases FAM13B; RHPN2; ARHGAP1; ARHGEF16; KTN1; KIF14; ARHGAP11A; RHOV; ARHGAP29B; CHN2

    CHN1 has several biochemical functions, for example, GTPase activator activity, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHN1 itself. We selected most functions CHN1 had, and list some proteins which have the same functions with CHN1. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity MYO9B; DAB2IPB; ARHGAP9; SRGAP2; ARHGEF6; RAP1GAP2B; ARHGAP18; SIPA1L2; FAM13B1; GAPVD1
    SH3/SH2 adaptor activity ITSN2; FCRL2; SKAP1; SH2B2; LASP1; SOCS2; SRC; SLA; SH2D3A; RUSC1
    ephrin receptor binding EFNB3; EFNB2A; EFNA2; CRK; EPHA4; CHN1; NTRK1; Anks1; CBL; NTRK3
    metal ion binding NENF; EFCAB5; TANK; YOD1; SALL4; PDE4C; ATP2B1; PDE8A; NT5C2B; OAS3
    protein binding DYNC1I1; ITGA1; ADAMTS3; SSH1; UBE2E3; CIB2; SSX2; FAM20A; AQP1; SLC25A10

    CHN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHN1.

    NCK2; HEMK1; CDK5R1; ERBB2; RPS3A; GTF3C1; MAPK8IP2

    Iwata, R; Ohi, K; et al. RacGAP alpha 2-Chimaerin Function in Development Adjusts Cognitive Ability in Adulthood. CELL REPORTS 8:1257-1264(2014).
    Ferreiro, JF; Rouhigharabaei, L; et al. Integrative Genomic and Transcriptomic Analysis Identified Candidate Genes Implicated in the Pathogenesis of Hepatosplenic T-Cell Lymphoma. PLOS ONE 9:-(2014).

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