Recombinant Human CPB2 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: CPB2-169H
• Product Overview: CPB2 MS Standard C13 and N15-labeled recombinant protein (NP_001863) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 48.4 kDa
• AA Sequence: MKLCSLAVLVPIVLFCEQHVFAFQS GQVLAALPRTSRQVQVLQNLTTTYE IVLWQPVTADLIVKKKQVHFFVNAS DVDNVKAHLNVSGIPCSVLLADVED LIQQQISNDTVSPRASASYYEQYHS LNEIYSWIEFITERHPDMLTKIHIG SSFEKYPLYVLKVSGKEQAAKNAIW IDCGIHAREWISPAFCLWFIGHITQ FYGIIGQYTNLLRLVDFYVMPVVNV DGYDYSWKKNRMWRKNRSFYANNHC IGTDLNRNFASKHWCEEGASSSSCS ETYCGLYPESEPEVKAVASFLRRNI NQIKAYISMHSYSQHIVFPYSYTRS KSKDHEELSLVASEAVRAIEKTSKN TRYTHGHGSETLYLAPGGGDDWIYD LGIKYSFTIELRDTGTYGFLLPERY IKPTCREAFAAVSKIAWHVIRNVTR TRPLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CPB2 carboxypeptidase B2 [ Homo sapiens (human) ]
• Official Symbol: CPB2
• Synonyms: CPB2; carboxypeptidase B2; CPU; PCPB; TAFI; carboxypeptidase B2; carboxypeptidase B-like protein; carboxypeptidase B2 (plasma); carboxypeptidase B2 (plasma, carboxypeptidase U); carboxypeptidase R; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor; EC 3.4.17.20
• Gene ID: 1361
• mRNA Refseq: NM_001872
• Protein Refseq: NP_001863
• MIM: 603101
• UniProt ID: Q96IY4