Recombinant Human CPB2 Protein, GST-tagged

• Cat.No.: CPB2-1778H
• Product Overview: Human CPB2 full-length ORF ( NP_001863.2, 1 a.a. - 423 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 74.8 kDa
• AA Sequence: MKLCSLAVLVPIVLFCEQHVFAFQS GQVLAALPRTSRQVQVLQNLTTTYE IVLWQPVTADLIVKKKQVHFFVNAS DVDNVKAHLNVSGIPCSVLLADVED LIQQQISNDTVSPRASASYYEQYHS LNEIYSWIEFITERHPDMLTKIHIG SSFEKYPLYVLKVSGKEQAAKNAIW IDCGIHAREWISPAFCLWFIGHITQ FYGIIGQYTNLLRLVDFYVMPVVNV DGYDYSWKKNRMWRKNRSFYANNHC IGTDLNRNFASKHWCEEGASSSSCS ETYCGLYPESEPEVKAVASFLRRNI NQIKAYISMHSYSQHIVFPYSYTRS KSKDHEELSLVASEAVRAIEKTSKN TRYTHGHGSETLYLAPGGGDDWIYD LGIKYSFTIELRDTGTYGFLLPERY IKPTCREAFAAVSKIAWHVIRNV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CPB2 carboxypeptidase B2 (plasma) [ Homo sapiens ]
• Official Symbol: CPB2
• Synonyms: CPB2; carboxypeptidase B2 (plasma); carboxypeptidase B2 (plasma, carboxypeptidase U); carboxypeptidase B2; carboxypeptidase R; carboxypeptidase U; CPU; PCPB; plasma carboxypeptidase B; TAFI; thrombin activatable fibrinolysis inhibitor; carboxypeptidase B-like protein; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor
• Gene ID: 1361
• mRNA Refseq: NM_001872
• Protein Refseq: NP_001863
• MIM: 603101
• UniProt ID: Q96IY4