Recombinant Human ERVW1 Protein (21-443 aa), His-SUMO-tagged
| Cat.No. : | ERVW1-1962H |
| Product Overview : | Recombinant Human ERVW1 Protein (21-443 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Cell Biology. Protein Description: Partial. |
- Specification
- Gene Information
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| Description : | This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His-SUMO |
| Form : | Tris-based buffer,50% glycerol |
| Molecular Mass : | 63.0 kDa |
| Protein length : | 21-443 aa |
| AA Sequence : | APPPCRCMTSSSPYQEFLWRMQRPG NIDAPSYRSLSKGTPTFTAHTHMPR NCYHSATLCMHANTHYWTGKMINPS CPGGLGVTVCWTYFTQTGMSDGGGV QDQAREKHVKEVISQLTRVHGTSSP YKGLDLSKLHETLRTHTRLVSLFNT TLTGLHEVSAQNPTNCWICLPLNFR PYVSIPVPEQWNNFSTEINTTSVLV GPLVSNLEITHTSNLTCVKFSNTTY TTNSQCIRWVTPPTQIVCLPSGIFF VCGTSAYRCLNGSSESMCFLSFLVP PMTIYTEQDLYSYVISKPRNKRVPI LPFVIGAGVLGALGTGIGGITTSTQ FYYKLSQELNGDMERVADSLVTLQD QLNSLAAVVLQNRRALDLLTAERGG TCLFLGEECCYYVNQSGIVTEKVKE IRDRIQRRAEELRNTGPWGLLSQ |
| Purity : | > 90% as determined by SDS-PAGE. |
| Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
| Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
| Concentration : | A hardcopy of COA with reconstitution instruction is sent along with the products. |
| Gene Name : | ERVW-1 endogenous retrovirus group W member 1, envelope [ Homo sapiens (human) ] |
| Official Symbol : | ERVW1 |
| Synonyms : | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV; |
| Gene ID : | 30816 |
| mRNA Refseq : | NM_001130925 |
| Protein Refseq : | NP_001124397 |
| UniProt ID : | Q9UQF0 |
Products Types
| ◆ Recombinant Protein | ||
| ERVW1-2428H | Recombinant Human ERVW1 Protein (21-443 aa), His-tagged | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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