| Description : |
This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
74 kDa |
| AA Sequence : |
MGLQTTKWPSHGAFFLKSWLIISLG LYSQVSKLLACPSVCRCDRNFVYCN ERSLTSVPLGIPEGVTVLYLHNNQI NNAGFPAELHNVQSVHTVYLYGNQL DEFPMNLPKNVRVLHLQENNIQTIS RAALAQLLKLEELHLDDNSISTVGV EDGAFREAISLKLLFLSKNHLSSVP VGLPVDLQELRVDENRIAVISDMAF QNLTSLERLIVDGNLLTNKGIAEGT FSHLTKLKEFSIVRNSLSHPPPDLP GTHLIRLYLQDNQINHIPLTAFSNL RKLERLDISNNQLRMLTQGVFDNLS NLKQLTARNNPWFCDCSIKWVTEWL KYIPSSLNVRGFMCQGPEQVRGMAV RELNMNLLSCPTTTPGLPLFTPAPS TASPTTQPPTLSIPNPSRSYTPPTP TTSKLPTIPDWDGRERVTPPISERI QLSIHFVNDTSIQVSWLSLFTVMAY KLTWVKMGHSLVGGIVQERIVSGEK QHLSLVNLEPRSTYRICLVPLDAFN YRAVEDTICSEATTHASYLNNGSNT ASSHEQTTSHSMGSPFLLAGLIGGA VIFVLVVLLSVFCWHMHKKGRYTSQ KWKYNRGRRKDDYCEAGTKKDNSIL EMTETSFQIVSLNNDQLLKGDFRLQ PIYTPNGGINYTDCHIPNNMRYCNS SVPDLEHCHTTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
