Recombinant Human KBTBD8 Protein (A2-L601), His/Strep tagged

• Cat.No.: KBTBD8-1242H
• Product Overview: Recombinant Human 8His-StrepII-TEV-(GG)-KBTBD8(A2-L601 end) Protein was expressed in Insect cell.

Specification

• Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
• Source: Insect cell
• Species: Human
• Tag: His/Strep
• Form: Liquid
• Protein Length: A2-L601
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: KBTBD8 kelch repeat and BTB (POZ) domain containing 8 [ Homo sapiens (human) ]
• Official Symbol: KBTBD8
• Synonyms: KBTBD8; kelch repeat and BTB (POZ) domain containing 8; kelch repeat and BTB domain-containing protein 8; KIAA1842; T cell activation kelch repeat protein; TA KRP; T-cell activation kelch repeat protein; TA-KRP; FLJ57592
• Gene ID: 84541
• mRNA Refseq: NM_032505
• Protein Refseq: NP_115894
• UniProt ID: Q8NFY9