Recombinant Mouse Kbtbd8 Protein, Myc/DDK-tagged

• Cat.No.: Kbtbd8-3652M
• Product Overview: Purified recombinant protein of mouse full-length kelch repeat and BTB (POZ) domain containing 8 (Kbtbd8), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
• Molecular Mass: 68.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Kbtbd8 kelch repeat and BTB (POZ) domain containing 8 [ Mus musculus (house mouse) ]
• Official Symbol: Kbtbd8
• Synonyms: KBTBD8; kelch repeat and BTB (POZ) domain containing 8; kelch repeat and BTB domain-containing protein 8; SSEC 51; T-cell activation kelch repeat protein; Takrp; SSEC51; SSEC-51; AU040152; mKIAA1842; MGC91215
• Gene ID: 243574
• mRNA Refseq: NM_001008785
• Protein Refseq: NP_001008785
• UniProt ID: Q3UQV5