Recombinant Human KMT5C(2-248) Protein

• Cat.No.: KMT5C-235H
• Product Overview: Recombinant human SUV4-20H2, amino acids 2-248, expressed in E.coli. Purified using immobilised metal affinity chromatography.

Specification

• Description: SUV4-20H2 (Suppressor of variegation 4-20 homolog 2) is a histone methyltransferase that adds methyl groups to histone H4 lysine 20 (H4K20), leading to the formation of the repressive chromatin mark H4K20me2 and H4K20me3. SUV4-20H2 is one of two paralogs of SUV4-20H family, which also includes SUV4-20H1. SUV4-20H2 is involved in the regulation of various cellular processes, including DNA damage response, heterochromatin formation, and telomere maintenance. It has been shown to play a role in the recruitment of DNA damage response factors to chromatin after DNA damage, and in the establishment of heterochromatin domains at repetitive DNA sequences, including telomeres. SUV4-20H2 is an important histone methyltransferase that plays a critical role in the regulation of gene expression and the maintenance of chromatin structure.
• Source: E. coli
• Species: Human
• Protein length: 2-248 aa
• Form: 1mg/ml of enzyme in 5mM Tris/HCl pH7.5, 250mM NaCl, 1.1mM DTT,50% Glycérol. Frozen solution.
• Molecular Mass: 28.1 kDa
• AA Sequence: 1 GGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP PLRRQQHLRS 51 ALETFLRQRD LEAAYRALTL GGWTARYFQS RGPRQEAALK THVYRYLRAF 101 LPESGFTILP CTRYSMETNG AKIVSTRAWK KNEKLELLVG CIAELREADE 151 GLLRAGENDF SIMYSTRKRS AQLWLGPAAF INHDCKPNCK FVPADGNAAC 201 VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CHTCERKGEG AFRTRPRE
• Applications: Drug Discovery & Development
• Storage: 1 year at -70 centigrade.
• Handling Advice: Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into prechilled micro-centrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade.
• Use/Stability: Stable for 1 year at -70 centigrade from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

Gene Information

• Gene Name: KMT5C lysine methyltransferase 5C [ Homo sapiens (human) ]
• Official Symbol: KMT5C
• Synonyms: KMT5C; lysine methyltransferase 5C; SUV420H2; Suv4-20h2
• Gene ID: 84787
• mRNA Refseq: NM_032701.4
• Protein Refseq: NP_116090.2
• MIM: 613198
• UniProt ID: Q86Y97