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Recombinant Human MME Protein, His-tagged

Cat.No.: MME-008H
Product Overview: Recombinant human cluster of differentiation 10 (rhCD10), Tyr52-Trp750 (Accession# NP_000893.2) was expressed in HEK293 cells.
Description: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
Source: HEK293 cells
Species: Human
Tag : His
Molecular Mass: rhCD10, fused with the 6×his at the N-terminus, and has a predicted molecular mass of 80.7 kDa. In DTT-reduced SDS-PAGE, rhCD10 protein migrates as 90-100 kDa poly peptide due to high glycosylation.
Endotoxin: Less than 0.01ng endotoxin per µg rhCD10.
Purity: >95% purity as determined by SDS-PAGE of reduced rhCD10.
Notes: Research Use Only. Not for use in diagnostic or therapeutic procedures.
Storage: Store at -20 centigrade in lyophilized state after receipt. For long term storage, upon reconstitution rhCD10 centigradeshould be aliquot and store at -20 centigrade or -8 centigrade centigrade. Avoid repeated freeze-thaw cycles.
Storage Buffer: Bulk protein in a 0.22 µm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
Gene Name: MME membrane metallo-endopeptidase [ Homo sapiens ]
Official Symbol: MME
Synonyms: MME; membrane metallo-endopeptidase; neprilysin; CALLA; CD10; enkephalinase; NEP; neutral endopeptidase; atriopeptidase; skin fibroblast elastase; neutral endopeptidase 24.11; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); SFE; MGC126681; MGC126707; DKFZp686O16152;
Gene ID: 4311
mRNA Refseq: NM_000902
Protein Refseq: NP_000893
MIM: 120520
UniProt ID: P08473

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