Recombinant Human MME Protein, GST-tagged

• Cat.No.: MME-5409H
• Product Overview: Human MME full-length ORF ( AAI01659.1, 1 a.a. - 750 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5 untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 111.9 kDa
• AA Sequence: MGKSESQMDITDINTPKPKKKQRWT PLEISLSVLVLLLTIIAVTMIALYA TYDDGICKSSDCIKSAARLIQNMDA TTEPCTDFFKYACGGWLKRNVIPET SSRYGNFDILRDELEVVLKDVLQEP KTEDIVAVQKAKALYRSCINESAID SRGGEPLLKLLPDIYGWPVATENWE QKYGASWTAEKAIAQLNSKYGKKVL INLFVGTDDKNSVNHVIHIDQPRLG LPSRDYYECTGIYKEACTAYVDFMI SVARLIRQEERLPIDENQLALEMNK VMELEKEIANATAKPEDRNDPMLLY NKMTLAQIQNNFSLEINGKPFSWLN FTNEIMSTVNISITNEEDVVVYAPE YLTKLKPILTKYSARDLQNLMSWRF IMDLVSSLSRTYKESRNAFRKALYG TTSETATWRRCANYVNGNMENAVGR LYVEAAFAGESKHVVEDLIAQIREV FIQTLDDLTWMDAETKKRAEEKALA IKERIGYPDDIVSNDNKLNNEYLEL NYKEDEYFENIIQNLKFSQSKQLKK LREKVDKDEWISGAAVVNAFYSSGR NQIVFPAGILQPPFFSAQQSNSLNY GGIGMVIGHEITHGFDDNGRNFNKD GDLVDWWTQQSASNFKEQSQCMVYQ YGNFSWDLAGGQHLNGINTLGENIA DNGGLGQAYRAYQNYIKKNGEEKLL PGLDLNHKQLFFLNFAQVWCGTYRP EYAVNSIKTDVHSPGNFRIIGTLQN SAEFSEAFHCRKNSYMNPEKKCRVW
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MME membrane metallo-endopeptidase [ Homo sapiens ]
• Official Symbol: MME
• Synonyms: MME; membrane metallo-endopeptidase; neprilysin; CALLA; CD10; enkephalinase; NEP; neutral endopeptidase; atriopeptidase; skin fibroblast elastase; neutral endopeptidase 24.11; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); SFE; MGC126681; MGC126707; DKFZp686O16152
• Gene ID: 4311
• mRNA Refseq: NM_000902
• Protein Refseq: NP_000893
• MIM: 120520
• UniProt ID: P08473