Recombinant Human PTPRN Protein, DDK-tagged

• Cat.No.: PTPRN-674H
• Product Overview: Purified recombinant protein of Human protein tyrosine phosphatase, receptor type, N (PTPRN), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9 insect cells.

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
• Source: Insect cell
• Species: Human
• Tag: DDK
• Molecular Mass: 103 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 50 mM Tris-HCl, pH8.0, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: PTPRN protein tyrosine phosphatase receptor type N [ Homo sapiens (human) ]
• Official Symbol: PTPRN
• Synonyms: PTPRN; protein tyrosine phosphatase receptor type N; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; insulinoma-associated tyrosine-phosphatase-like protein; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; EC 3.1.3.48
• Gene ID: 5798
• mRNA Refseq: NM_002846
• Protein Refseq: NP_002837
• MIM: 601773
• UniProt ID: Q16849