PTPRN2
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Official Full Name
protein tyrosine phosphatase, receptor type, N polypeptide 2
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Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. -
Synonyms
PTPRN2; protein tyrosine phosphatase, receptor type, N polypeptide 2; receptor-type tyrosine-protein phosphatase N2; IA 2beta; IAR PTPRP; ICAAR; KIAA0387; phogrin; tyrosine phosphatase IA-2 beta; islet cell autoantigen-related protein; protein tyrosine ph;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
PTPRN2 involved in several pathways and played different roles in them. We selected most pathways PTPRN2 participated on our site, such as Type I diabetes mellitus, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Type I diabetes mellitus | GAD1;PTPRN;CD86;HLA-DMA;HLA-DRB3;Fasl;IFNG;PTPRN2;INS1 |
PTPRN2 has several biochemical functions, for example, transmembrane receptor protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRN2 itself. We selected most functions PTPRN2 had, and list some proteins which have the same functions with PTPRN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane receptor protein tyrosine phosphatase activity | PTPRUB;EVLA;PTPRE;PTPRM;PTPRO;PTPRD;PTPN6;PTPRS;PTPRB |
PTPRN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRN2.
NR3C1; GRB2; CKAP5; SPTBN4; UBQLN4; q9wmx2-pro_0000037548
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