Recombinant Human Ret Proto-Oncogene, GST-His-tagged
Cat.No. : | RET-5476H |
Product Overview : | Recombinant humanRET contains amino acids H658-D1110 (as in GenBank entry NM_000323) and isN-terminally fused to GST-His6-Thrombin cleavage site. |
- Specification
- Gene Information
- Related Products
Cat. No. : | RET-5476H |
Description : | The RETproto-oncogene encodes a receptor tyrosine kinase for members of the glialcell line-derived neurotrophic factor family of extracellular signallingmolecules. RET loss of function mutations are associated with the developmentof Hirschsprung" s disease, while gain of function mutations are associatedwith the development of various types of human cancer. |
Source : | Sf9 insect cells |
Species : | Human |
Form : | Liquid in 50 mMTris-HCl, pH 8.0 + 100 mM NaCl + 5 mM DTT + 15 mM reduced glutathione + 20%glycerol. |
MolecularWeight : | 84.322 kDa |
Specific Activity : | 24 pmol/μg x min.Assay conditions: 60 mM HEPES-NaOH, pH 7.5 + 3 mM MgCl2 + 3 mMMnCl2 + 3 μM Na-orthovanadate + 1.2 mM DTT + 2.5 μg / 50 μl PEG20.000+ ATP (variable) + 2 μg / 50 μl Poly(Glu:Tyr)4:1 substrate + 200ng / 50 μl recombinant RET. |
Concentration : | 0.131 mg/ml |
Storage : | Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | RET |
Pathways : | Endocytosis;Pathways in cancer; SIDS Susceptibility Pathways; Signaling events regulatedby Ret tyrosine kinase; Thyroid cancer |
Gene Name : | RET ret proto-oncogene [ Homosapiens ] |
Synonyms : | RET; retproto-oncogene; PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16;RET-ELE1; proto-oncogenetyrosine-protein kinase receptor Ret; OTTHUMP00000019479; OTTHUMP00000216967;proto-oncogene c-Ret; receptor tyrosine kinase; RET transforming sequence; cadherinfamily member 12; hydroxyaryl-protein kinase; cadherin-related family member16; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroidcarcinoma 1, Hirschsprung disease); EC 2.7.10.1; Proto-oncogene tyrosine-protein kinasereceptor Ret; Cadherinfamily member 12; Proto-oncogene c-Ret |
Gene ID : | 5979 |
mRNA Refseq : | NM_020630 |
Protein Refseq : | NP_065681 |
MIM : | 164761 |
UniProt ID : | P07949 |
Chromosome Location : | 10q11.2 |
Function : | ATP binding; calciumion binding; nucleotide binding; protein binding; protein tyrosine kinaseactivity; receptor activity; transmembrane receptor protein tyrosine kinaseactivity |
Products Types
◆ Recombinant Protein | ||
Ret-10611M | Recombinant Mouse Ret Protein, His (Fc)-Avi-tagged | +Inquiry |
RET-716H | Recombinant Human RET Protein, His-tagged | +Inquiry |
RET-5475H | Recombinant Human Ret Proto-Oncogene, GST-tagged | +Inquiry |
Ret-2014M | Recombinant Mouse Ret Protein, His-tagged | +Inquiry |
RET-7010H | Recombinant Human RET protein(Met1-Arg635), His-tagged | +Inquiry |
◆ Lysates | ||
RET-1822HCL | Recombinant Human RET cell lysate | +Inquiry |
RET-570HCL | Recombinant Human RET cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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