RET

  • Official Full Name

    ret proto-oncogene

  • Overview

    This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
  • Synonyms

    RET; ret proto-oncogene; PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16; RET-ELE1; proto-oncogene tyrosine-protein kinase receptor Ret; proto-oncogene c-Ret; receptor tyrosine kinase; RET transforming sequence; cadherin family member 12; hydroxyaryl-protein kinase; cadherin-related family member 16; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Aspergillus restrictus
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • C
  • His
  • DDK
  • DDK|His
  • Flag
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RET-292H Active Recombinant Human RET protein, His-tagged Insect Cell His
Human RET-291H Active Recombinant Human RET protein, His-tagged Insect Cell His
Human RET-1928H Active Recombinant Human Ret Proto-oncogene, His-tagged Sf21 Insect Cell His
Human RET-293H Active Recombinant Human RET protein, His-tagged Insect Cell His
Human RET-290H Active Recombinant Human RET protein, His-tagged Insect Cell His
Human RET-16H Recombinant Human RET (G691S), GST-tagged Sf9 Insect Cell GST
Human RET-686H Recombinant Human RET Protein, DDK-tagged Sf9 Insect Cell DDK
Human RET-685H Recombinant Human RET Protein, DDK-tagged Sf9 Insect Cell DDK
Human RET-684H Recombinant Human RET Protein, DDK/His-tagged HEK293 DDK/His
Human RET-53H Recombinant Human RET (L790F), GST-tagged Sf9 Insect Cell GST
Human RET-716H Recombinant Human RET Protein, His-tagged CHO His
Human RET-35H Recombinant Human RET (E762Q), GST-tagged Sf9 Insect Cell GST
Human RET-7010H Recombinant Human RET protein(Met1-Arg635), His-tagged HEK293 C-His
Human RET-65H Recombinant Human RET (M918T), GST-tagged Sf9 Insect Cell GST
Human RET-5476H Recombinant Human Ret Proto-Oncogene, GST-His-tagged Sf9 Insect Cell GST/His
Human RET-37H Recombinant Human RET (R813Q), GST-tagged Sf9 Insect Cell GST
Human RET-38H Recombinant Human RET (A883F), GST-tagged Sf9 Insect Cell GST
Human RET-34H Recombinant Human RET (R749T), GST-tagged Sf9 Insect Cell GST
Human RET-5475H Recombinant Human Ret Proto-Oncogene, GST-tagged Insect Cell GST
Human RET-52H Recombinant Human RET (V778I), GST-tagged Sf9 Insect Cell GST
Human RET-64H Recombinant Human RET (S891A), GST-tagged Sf9 Insect Cell GST
Human RET-75H Recombinant Human RET protein, Flag-tagged, Biotinylated Insect Cell Flag
Human RET-1850H Recombinant Human Ret Proto-Oncogene, GST-tagged Sf9 Insect Cell GST
Human RET-417H Recombinant Human Ret Proto-oncogene, GST-tagged, Active Sf9 Insect Cell GST
Human RET-36H Recombinant Human RET (V804M), GST-tagged Sf9 Insect Cell GST
Human RET-3948H Recombinant Human RET, His & GST tagged Insect Cell His/GST
Human RET-1822HCL Recombinant Human RET cell lysate Human Cell N/A
Human RET-570HCL Recombinant Human RET cell lysate Insect Cell N/A
Human RET-7010HAF488 Recombinant Human RET Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Human RET-3948HAF555 Recombinant Human RET Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cells His/GST
Human RET-91H Active Recombinant Human RET Protein, GST-His-tagged Insect cell GST/His
Human RET-3948HAF488 Recombinant Human RET Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cells His/GST
Human RET-2652H Recombinant Human RET Protein, His-tagged E.coli N-His
Human RET-7010HAF555 Recombinant Human RET Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Human RET-2214H Active Recombinant Human RET protein, His&GST-tagged Insect Cells His/GST
Human RET-3948HF Recombinant Human RET Protein, His/GST-tagged, FITC conjugated Insect Cells His/GST
Human RET-3948HAF647 Recombinant Human RET Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cells His/GST
Human RET-7010HAF647 Recombinant Human RET Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Human RET-7010HF Recombinant Human RET Protein, His-tagged, FITC conjugated HEK293 His
Human RET-6175H Recombinant Human RET Protein (Leu29-Arg635), N-His tagged E.coli N-His
Mouse Ret-18M Active Recombinant Mouse Ret/FC Chimera Sf21 Insect Cell N/A
Mouse Ret-1776M Recombinant Mouse Ret Proto-oncogene Mammalian cells N/A
Mouse RET-14085M Recombinant Mouse RET Protein Mammalian Cell His
Mouse Ret-10611M Recombinant Mouse Ret Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ret-2014M Recombinant Mouse Ret Protein, His-tagged E.coli N-His
Mouse Ret-10611M-B Recombinant Mouse Ret Protein Pre-coupled Magnetic Beads HEK293
Aspergillus restrictus ret-3715A Recombinant Aspergillus restrictus ret protein, His&Myc-tagged E.coli His&Myc
Zebrafish RET-9631Z Recombinant Zebrafish RET Mammalian Cell His
Chicken RET-6744C Recombinant Chicken RET Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RET Related Articles
  • RET Related Research Area

RET involved in several pathways and played different roles in them. We selected most pathways RET participated on our site, such as Endocytosis, Pathways in cancer, Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RET were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisSTAMBP;VPS26A;CAPZA3;RAB4A;PARD6A;PARD6GA;DAB2;PIP5K1AA;LDLRAP1A
Pathways in cancerBIRC8;TRAF3;ITGA2;PRKACG;CTBP2;HSP90AB1;PRKACA;PPARD;BIRC3
Thyroid cancerTCF7L2;RET;MAP2K2;TFG;TPR;NRAS;CCDC6;TCF7;NTRK1
Central carbon metabolism in cancerPIK3R1;AKT2;PIK3R5;SIRT3;ERBB2;PIK3CD;GLS;MTOR;NTRK3

RET has several biochemical functions, for example, ATP binding, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RET itself. We selected most functions RET had, and list some proteins which have the same functions with RET. You can find most of the proteins on our site.

Function Related Protein
ATP bindingACSF2;ACTG2;TSSK6;ATP2B1A;PNKP;SGK1;Atp8a2;PDPK1B;DHX32
calcium ion bindingLCP1;PLCB2;PCDH1G22;HPCAL4;PROS1;SPTAN1;Amy1;EFCAB12;PCDHGC4
protein bindingRP2;PDGFB;ERC1;MXD1;ARVCF;ENC1;MYC;DPEP3;GCET2
protein tyrosine kinase activityABL2;ERBB4;BMX;MAP2K3;FYNB;BCR;MAP2K4;NTRK2B;FGFR4
receptor activityVMN1R47;CRLF1;NLGN2A;ATRN;LDLR;NLGN4B;ITGB3A;NPR2;SMAGP
transmembrane receptor protein tyrosine kinase activityAXL;FGFR1B;CSF1RA;EPHB2B;TEK;EPHB3A;PDGFRA;INSRR;EPHB4A

RET has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RET here. Most of them are supplied by our site. Hope this information will be useful for your research of RET.

CBL; Sh2b1; PLCG1; STAT3; NOTCH2NL; Plcg1

Gurzu, S; Ciortea, D; et al. The immunohistochemical profile of granular cell (Abrikossoff) tumor suggests an endomesenchymal origin. ARCHIVES OF DERMATOLOGICAL RESEARCH 307:151-157(2015).
Doberstein, K; Harter, PN; et al. Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT. INTERNATIONAL JOURNAL OF CANCER 136:E326-E339(2015).
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