RET
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Official Full Name
ret proto-oncogene
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Overview
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008] -
Synonyms
RET; ret proto-oncogene; PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16; RET-ELE1; proto-oncogene tyrosine-protein kinase receptor Ret; proto-oncogene c-Ret; receptor tyrosine kinase; RET transforming sequence; cadherin family member 12; hydroxyaryl-protein kinase; cadherin-related family member 16; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Aspergillus restrictus
- Chicken
- Human
- Human
- Mouse
- Zebrafish
- CHO
- E.coli
- HEK293
- Human Cell
- Insect cell
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf21 Insect Cell
- Sf9 Insect Cell
- C
- His
- DDK
- DDK|His
- Flag
- GST
- GST|His
- His (Fc)
- Avi
- Myc
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- RET Related Articles
- RET Related Research Area
RET involved in several pathways and played different roles in them. We selected most pathways RET participated on our site, such as Endocytosis, Pathways in cancer, Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RET were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | EEA1;ARRB2B;PIP5K1BB;GIT2A;WASB;VPS29;PIP5KL1;SH3GL1;WASLA |
| Pathways in cancer | PTGER2;MLH1;GNB1;NOS2;ARAF;PDGFRB;PTGER3;IL6;TRAF4 |
| Thyroid cancer | LEF1;TPR;KRAS;MAP2K2;HRAS;MAPK3;NTRK1;RXRB;TFG |
| Central carbon metabolism in cancer | PIK3CD;HK1;PDHB;PIK3CA;FGFR3;AKT1;PIK3CB;PDHA1;TRP53 |
RET has several biochemical functions, for example, ATP binding, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RET itself. We selected most functions RET had, and list some proteins which have the same functions with RET. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | AK9;PDPK1;GTF2F2;PIK3C3;GNE;PAPOLA;KIF5C;WARS2;EPHB2B |
| calcium ion binding | SVEP1;PKD2L1;UBE4A;HSPA5;MMP20;CALB2B;MMP14A;MGP;SLC24A1 |
| protein binding | TRIM27;RAB5C;PSMG1;NETO2;EEA1;PCSK2;KRT8;EIF2A;CTNNA3 |
| protein tyrosine kinase activity | YES1;MAP2K2;KITA;NTRK3A;TEK;FGR;LYN;PDGFRB;SRMS |
| receptor activity | MED4;CD40;NLGN4A;CMKLR1;ADIPOR1B;NLGN2;NOTCH1;CHRM3;GUCY1B3 |
| transmembrane receptor protein tyrosine kinase activity | KDRL;TEK;TYRO3;ERBB2;AXL;INSRA;EGFRA;KITB;EPHB2B |
RET has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RET here. Most of them are supplied by our site. Hope this information will be useful for your research of RET.
CBL; Sh2b1; PLCG1; STAT3; NOTCH2NL; Plcg1
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