Recombinant Human UHRF1 Protein, His-tagged

• Cat.No.: UHRF1-131H
• Product Overview: Recombinant Human UHRF1 Protein, fused to His-tag, was expressed in E. coli.

Specification

• Description: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v).
• Molecular Mass: 92.4 kDa
• Purity: >90%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.1 mg/ml

Gene Information

• Gene Name: UHRF1 ubiquitin like with PHD and ring finger domains 1 [ Homo sapiens (human) ]
• Official Symbol: UHRF1
• Synonyms: Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95
• Gene ID: 29128
• mRNA Refseq: NM_001048201
• Protein Refseq: NP_001041666
• MIM: 607990
• UniProt ID: Q96T88