UHRF2

  • Official Full Name

    ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase

  • Overview

    This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.

  • Synonyms

    UHRF2;ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase;ubiquitin like with PHD and ring finger domains 2;E3 ubiquitin-protein ligase UHRF2;MGC33463;NIRF;Np95 like ring finger protein;RNF107;URF2;nuclear protein 97;R

Recombinant Proteins

  • Human
  • Mouse
  • HEK293
  • Mammalian Cells
  • E.coli
  • DDK
  • Myc
  • His
  • Non
  • SUMO
  • GST
  • Avi
  • Fc

    Involved Pathway

    UHRF2 involved in several pathways and played different roles in them. We selected most pathways UHRF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UHRF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    UHRF2 has several biochemical functions, for example, DNA binding,histone binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UHRF2 itself. We selected most functions UHRF2 had, and list some proteins which have the same functions with UHRF2. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin protein ligase activity UBE2N,HLTF,MED7,AMFR,STUB1,MARCH1,PDZD4,UBE2V2,BTRC,MED20
    ubiquitin-protein transferase activity TRIM33,BIRC5B,UBE2D1,TTC3,TRIM23,FBXL5,RNF6,WWP2,UBE2L3,TRIM28
    ligase activity RNF149,TRIM24,RNF2,TRIM5,LTN1,DTX2,RNF31,TTLL5,MARCH3,HECTD3
    zinc ion binding TRIM35-22,ZRANB3,KDM4A,LIMA1,PDZRN4,GATA4,DUSP12,ZDHHC23B,CXXC5,ADAMTS10
    DNA binding ZNF507,TSG101,MCM3AP,RNF4,ZFP1,SIX4A,DNAJC2,HIST2H2AA4,FAM60AL,HIST1H3H
    histone binding HIST1H4J,HIST1H4H,SMARCA4A,CTSL1,HIST2H4,BRDT,LEF1,HIST1H47,ATAD2,CD1D
    protein binding JAG1,YWHAH,COL6A5,NRIP3,DNER,SCLY,ERCC6L,CMTM2A,VARS2,CASR

    Interacting Protein

    UHRF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UHRF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UHRF2.

    CDK2;CCND1;CCNE1;RB1;TP53

    Resources

    References

    • Zhou, T; Xiong, J; et al. Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. MOLECULAR CELL 54:879-886(2014).
    • Lu, S; Yan, DW; et al. Ubiquitin-like with PHD and ring finger domains 2 is a predictor of survival and a potential therapeutic target in colon cancer. ONCOLOGY REPORTS 31:1802-1810(2014).

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