Recombinant Mouse Cntn1 Protein, Myc/DDK-tagged

• Cat.No.: Cntn1-2228M
• Product Overview: Purified recombinant protein of mouse full-length contactin 1 (Cntn1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 113.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cntn1 contactin 1 [ Mus musculus (house mouse) ]
• Official Symbol: Cntn1
• Synonyms: CNTN1; contactin 1; contactin-1; neural cell surface protein F3; CNTN; F3cam; AW495098
• Gene ID: 12805
• mRNA Refseq: NM_007727
• Protein Refseq: NP_031753
• UniProt ID: P12960