Recombinant Mouse Nrarp Protein, Myc/DDK-tagged

• Cat.No.: Nrarp-4493M
• Product Overview: Purified recombinant protein of mouse full-length Notch-regulated ankyrin repeat protein (Nrarp), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in the regulation of canonical Wnt signaling by stabilizing LEF1. Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis. During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 12.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Nrarp Notch-regulated ankyrin repeat protein [ Mus musculus (house mouse) ]
• Official Symbol: Nrarp
• Synonyms: NRARP; Notch-regulated ankyrin repeat protein; notch-regulated ankyrin repeat-containing protein; 2700054M22Rik
• Gene ID: 67122
• mRNA Refseq: NM_025980
• Protein Refseq: NP_080256
• UniProt ID: Q91ZA8