Recombinant Mouse Pagr1a Protein, Myc/DDK-tagged
| Cat.No. : | Pagr1a-4658M |
| Product Overview : | Purified recombinant protein of mouse full-length PAXIP1 associated glutamate rich protein 1A (Pagr1a), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
| Description : | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent. May be involved in the regulation of the BMP pathway in extraembryonic development. |
| Source : | HEK293T |
| Species : | Mouse |
| Tag : | Myc/DDK |
| Molecular Mass : | 27.7 kDa |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : | Store at -80 centigrade after receiving vials. |
| Concentration : | >50 μg/mL as determined by microplate BCA method |
| Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Gene Name : | Pagr1a PAXIP1 associated glutamate rich protein 1A [ Mus musculus (house mouse) ] |
| Official Symbol : | Pagr1a |
| Synonyms : | Pagr1a; PAXIP1 associated glutamate rich protein 1A; P; PA1; PAGR1; C77040; 2900092E17Rik; PAXIP1-associated glutamate-rich protein 1A; PAXIP1-associated glutamate-rich protein 1; PAXIP1-associated protein 1; PTIP-associated 1; PTIP-associated protein 1 |
| Gene ID : | 67278 |
| mRNA Refseq : | NM_030240 |
| Protein Refseq : | NP_084516 |
| UniProt ID : | Q99L02 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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