"OSM" Related Products

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Recombinant Human Oncostatin M, His-tagged

Cat. No.: OSM-346H
Product Overview: Recombinanthuman OSM wasexpressed in E.coliusing a N-terminal His tag.
Description: OSM, also known as Oncostatin M, isa pleiotropic cytokine that belongs to the interleukin 6 group of cytokines.Of these cytokines it most closely resembles leukemia inhibitory factor (LIF)in both structure and function. However, it is as yet poorly defined and isproving important in liver development, haematopoeisis, inflammation andpossibly CNS development. It is also associated with bone formation anddestruction. OSM signals through cell surface receptors that contain theprotein gp130. The type I receptor is composed of gp130 and LIFR, the type IIreceptor is composed of gp130 and OSMR. Recombinant human OSM protein, fusedto His-tag at N-terminus, was expressed in E. coli and purified by usingconventional chromatography.
Concentration: 0.5 mg/ml
Source: Human
Host: E.coli
Form: Supplied as aliquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol and 1mM DTT.
Purity: > 95% by SDS - PAGE
Sequence: 26-234 amino acids: MGSSHHHHHHSSGLVPRGSH MAAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSEETLRGLGRRG FLQTLNATLG CVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMAQLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRF LHGYHRFMHS VGRVFSKWGE SPNR
Molecular Mass: 26 kDa
Applications: SDS-PAGE
Storage: Store at 4 deg Cfor short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70deg C for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol: OSM
Gene Name: OSM oncostatin M [ Homo sapiens ]
Synonyms: OSM; oncostatin M;MGC20461; oncostatin-M; OTTHUMP00000198700
Gene ID: 5008
mRNA Refseq: NM_020530
Protein Refseq: NP_065391
MIM: 165095
UniProt ID: P13725
Chromosome Location: 22q12.2
Pathway: Adipogenesis;Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: cytokineactivity; growth factor activity; oncostatin-M receptor binding

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