"SERPINC1" Related Products

Recombinant Human SERPINC1, His-tagged

Cat.No.: SERPINC1-7274H
Product Overview: A DNA sequence encoding the Human SerpinC1 (Met 1-Lys 464) was expressed in Human Cells, with a C-terminal His tag.
Description: SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization.
Source: Human Cells
Species: Human
Tag: His
Predicted N Terminal: His 33
Form: Lyophilized from sterile PBS , pH 7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Bio-activity: Measured by its ability to inhibit thrombin cleavage of a fluorogenic peptide substrate Boc-VPR-AMC. The IC50 value is< 5>
Molecular Mass: The recombinant protein consists of 443 amino acids and has a predicted molecular mass of 50.5 kDa. In SDS-PAGE, the apparent molecular mass of rhSerpinC1 is approximately 55-60 kDa due to glycosylation
Endotoxin: 1.0 eu/μg of the protein as determined by the lal
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name: SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 [ Homo sapiens ]
Official Symbol: SERPINC1
Synonyms: SERPINC1; serpin peptidase inhibitor, clade C (antithrombin), member 1; AT3, serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; antithrombin-III; antithrombin (aa 375 432); antithrombin III; ATIII; coding sequence signal peptide antithrombin part 1; MGC22579; signal peptide antithrombin part 1; serpin C1; serine-cysteine proteinase inhibitor clade C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; AT3; AT3D; THPH7;
Gene ID: 462
mRNA Refseq: NM_000488
Protein Refseq: NP_000479
MIM: 107300
UniProt ID: P01008
Chromosome Location: 1q23-q25.1
Pathway: Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Glypican 1 network, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function: heparin binding; peptidase inhibitor activity; protease binding; protein binding; serine-type endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity;

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