Recombinant Human SERPINC1 Protein, His-tagged

• Cat.No.: SERPINC1-539H
• Product Overview: Recombinant Human SERPINC1(His33~Lys464) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 50.1kDa
• Protein length: His33~Lys464
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 [ Homo sapiens ]
• Official Symbol: SERPINC1
• Synonyms: SERPINC1; serpin peptidase inhibitor, clade C (antithrombin), member 1; AT3, serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; antithrombin-III; antithrombin (aa 375 432); antithrombin III; ATIII; coding sequence signal peptide antithrombin part 1; MGC22579; signal peptide antithrombin part 1; serpin C1; serine-cysteine proteinase inhibitor clade C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; AT3; AT3D; THPH7
• Gene ID: 462
• mRNA Refseq: NM_000488
• Protein Refseq: NP_000479
• MIM: 107300
• UniProt ID: P01008