Recombinant Human SERPINC1 Protein, His-tagged

• Cat.No.: SERPINC1-001H
• Product Overview: Recombinant human SERPINC1 (33-464aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Specification

• Description: SERPINC1, also known as antithrombin-III, is a member of the Serpin superfamily of the serine protease inhibitors. It is the principal plasma Serpin of blood clotting proteases and inhibits thrombin as well as several factors such as Xa. It is one of the most important coagulation inhibitors and is the basic enzyme for the therapeutic action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 dramatically increases the presence of heparin and other glycosaminoglycans. It mediates the promotion of prostaglandin release, inhibitors of leukocyte activation and down-regulation of many inflammatory cytokines. This protein has anti-inflammatory properties besides anticoagulant.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Molecular Mass: 50.1 kDa
• AASequence: ADPHGSPVDICTAKPRDIPMNPMCI YRSPEKKATEDEGSEQKIPEATNRR VWELSKANSRFATTFYQHLADSKND NDNIFLSPLSISTAFAMTKLGACND TLQQLMEVFKFDTISEKTSDQIHFF FAKLNCRLYRKANKSSKLVSANRLF GDKSLTFNETYQDISELVYGAKLQP LDFKENAEQSRAAINKWVSNKTEGR ITDVIPSEAINELTVLVLVNTIYFK GLWKSKFSPENTRKELFYKADGESC SASMMYQEGKFRYRRVAEGTQVLEL PFKGDDITMVLILPKPEKSLAKVEK ELTPEVLQEWLDELEEMMLVVHMPR FRIEDGFSLKEQLQDMGLVDLFSPE KSKLPGIVAEGRDDLYVSDAFHKAF LEVNEEGSEAAASTAVVIAGRSLNP NRVTFKANRPFLVFIREVPLNTIIF MGRVANPCVKHHHHHH
• N-terminal Sequence Analysis: Ala
• Endotoxin: < 1.0 EU per 1 μg of protein (determined by LAL method)
• Purity: > 90% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/mL (determined by Absorbance at 280nm)
• Storage Buffer: In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Warning: For research use only. This product is not intended or approved for human, diagnostics or veterin

Gene Information

• Gene Name: SERPINC1 serpin family C member 1 [ Homo sapiens (human) ]
• Official Symbol: SERPINC1
• Synonyms: SERPINC1; serpin family C member 1; AT3; AT3D; ATIII; THPH7; ATIII-R2; antithrombin-III; antithrombin III isoform; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1
• Gene ID: 462
• mRNA Refseq: NM_000488
• Protein Refseq: NP_000479
• MIM: 107300
• UniProt ID: P01008