"NFKB2" Related Products

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Recombinant Human NFKB2, GST-tagged

Cat.No.: NFKB2-4859H
Product Overview: Recombinant human NFKB2 (1-454) was expressed in Sf9 insect cells using an N-terminal GST tag.
Description: This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.?
Source: Sf9 insect cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~84 kDa
Protein length: 1-454
Purity: >75%
Applications: Western Blot
Stability: 1 yr at -70oC from date of shipment.
Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.2 ug/ul
Gene Name: NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [ Homo sapiens ]
Official Symbol: NFKB2
Synonyms: NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor NF-kappa-B p100 subunit; LYT 10; NF kB2; p52; p105; oncogene Lyt-10; DNA-binding factor KBF2; lymphocyte translocation chromosome 10 protein; nuclear factor of kappa light chain gene enhancer in B-cells 2; H2TF1; LYT10; LYT-10; NF-kB2
Gene ID: 4791
mRNA Refseq: NM_002502
Protein Refseq: NP_002493
MIM: 164012
UniProt ID: Q00653
Chromosome Location: 10q24
Pathway: Cytokine Signaling in Immune system; DEx/H-box helicases activate type I IFN and inflammatory cytokines production; Epstein-Barr virus infection
Function: DNA binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity

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