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NFKB2

  • Official Full Name

    nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

  • Overview

    This gene encodes one of the NF-kappaB family of transcription factors which are characterized by a Rel homology domain (RHD) in the N-terminal region. These transcription factors have key roles in regulating immunity, stress responses, apoptosis, and differentiation. The p100 form of this gene is processed in the proteasome to the p52 form. NF-kappaB molecules containing p52 participate in noncanonical NF-kappaB regulatory pathways. Recent reviews of the NF-kappaB signalling pathways include PubMed 17072323, 18267068, 18515173, and 21772278.
  • Synonyms

    NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor NF-kappa-B p100 subunit; LYT 10; NF kB2; p52; p105; oncogene Lyt-10; DNA-binding factor KBF2; lymphocyte translocation chromosome 10 protein; nuclear fa;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NFKB2-7052H Recombinant Human NFKB2, GST-tagged Sf9 Insect Cell GST 1-454 aa
Human NFKB2-306H Recombinant Human NFKB2 protein, His/MBP-tagged E.coli His/MBP 698-900 aa
Human NFKB2-1280H Recombinant Human NFKB2 protein, GST-tagged E.coli GST 600-899 aa
Human NFKB2-4859H Recombinant Human NFKB2, GST-tagged Sf9 Insect Cell GST 1-454
Human NFKB2-4859 Recombinant Human NFKB2 protein, GST-tagged Insect Cell GST 1-454
Human NFKB2-815H Recombinant Human NFKB2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NFKB2-1507H Recombinant Human NFKB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NFKB2-2608H Recombinant Human NFKB2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NFKB2-4888H Recombinant Human NFKB2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NFKB2-305H Recombinant Human NFKB2 protein, His-tagged E.coli His 600-899 aa
Human NFKB2-1507H-B Recombinant Human NFKB2 Protein Pre-coupled Magnetic Beads HEK293
Human NFKB2-559HFL Recombinant Full Length Human NFKB2 Protein, C-Flag-tagged Mammalian cells Flag
Human NFKB2-303H Recombinant Human NFKB2 protein, His-tagged E.coli His Pro38~Leu343
Human NFKB2-4691H Recombinant Human NFKB2 Protein (1-447), His tagged E.coli His 1-447
Human NFKB2-4692H Recombinant Human NFKB2 Protein (Pro38-Leu343), N-His tagged E.coli N-His Pro38-Leu343
Mouse Nfkb2-1851M Recombinant Mouse Nfkb2 protein, His & T7-tagged E.coli His/T7 Ala35~Gly224 ((Accession # Q9WTK5)
Mouse Nfkb2-4397M Recombinant Mouse Nfkb2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish NFKB2-249Z Recombinant Zebrafish NFKB2 Mammalian Cell His
Chicken NFKB2-1850C Recombinant Chicken NFKB2 protein, His & T7-tagged E.coli His/T7 Pro37~Leu342 (Accession # P98150)
Chicken NFKB2-5983C Recombinant Chicken NFKB2 Mammalian Cell His
Chicken NFKB2-1149C Recombinant Chicken NFKB2 Protein, His-tagged E.coli N-His Ala34-Gly223
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NFKB2 Related Articles
  • NFKB2 Related Signal Pathway

NFKB2 involved in several pathways and played different roles in them. We selected most pathways NFKB2 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayMAP3K5;STMN1B;MAPK8;CACNG7A;MKNK2;MAPK1;ATF4B1;TAB2;RAF1B
NF-kappa B signaling pathwayPTGS2;PLAU;LTA;CFLAR;LCK;RELB;XIAP;TNF;TNFSF14
Osteoclast differentiationMAPK10;SIRPB1;MAP3K7;CYBA;LILRA1;PIK3R3;LILRA4;LILRA5;OSCAR
LegionellosisCXCL2;EEF1A1;CR1;BCL2L13;NLRC4;SAR1B;CASP8;CASP7;TLR4
HTLV-I infectionPIK3CD;H2-AB1;VDAC2;ATM;RAN;WNT7B;VDAC1;CD40;WNT7A
Epstein-Barr virus infectionPOLR2J;PSMD7;POLR2A;NFKBIE;NFKB1;HLA-C;YWHAB;HLA-DPB1;POLR2H
Pathways in cancerAHA-1;XIAP;FGF21;FGF20;WNT7A;APC;SMO;RB1;SMAD2
Viral carcinogenesisATP6V0D1;PKM;HIST1H4H;HIST1H4E;CREB3L3;BAD;MAPK1;GTF2A2;GTF2H2

NFKB2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKB2 itself. We selected most functions NFKB2 had, and list some proteins which have the same functions with NFKB2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingTCF3A;PRDM1;MYPOP;SREBF2;BSX;RFX5;EBF1;ARID3B;TFAP2A
chromatin bindingRBPJL;EOMES;RCC1;WDHD1;MEIOB;SIN3A;SP140L;TICRR;POU1F1
protein bindingCD22;NAPB;FGF21;DDIT4L;NPDC1;PAXIP1;AQP1;SEPT6;AZU1
transcription coactivator activityNFE2L3;GATA4;CTBP2;E4F1;BRCA1;TGFB1I1;TADA3;MLL5;CITED2
transcription factor activity, sequence-specific DNA bindingZNF354B;PITX2;CITED1;RNF4;FOXI3A;EF1;AHR;KLF3;NFKB2
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingNR4A1;SMAD2;ZFP292;FOS;TFE3A;NCOA3;MEIS3;HOXA7;NFIA

NFKB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKB2.

NFKB1; MAP3K8; RELB; REL; EPS8

Lee, CE; Fulcher, DA; et al. Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. BLOOD 124:2964-2972(2014).
Chen, K; Coonrod, EM; et al. Germline Mutations in NFKB2 Implicate the Noncanonical NF-kappa B Pathway in the Pathogenesis of Common Variable Immunodeficiency. AMERICAN JOURNAL OF HUMAN GENETICS 93:812-824(2013).
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