nfkb2 Protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)


Home / Products / nfkb2


Official Full Name nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Background This gene encodes one of the NF-kappaB family of transcription factors which are characterized by a Rel homology domain (RHD) in the N-terminal region. These transcription factors have key roles in regulating immunity, stress responses, apoptosis, and differentiation. The p100 form of this gene is processed in the proteasome to the p52 form. NF-kappaB molecules containing p52 participate in noncanonical NF-kappaB regulatory pathways. Recent reviews of the NF-kappaB signalling pathways include PubMed 17072323, 18267068, 18515173, and 21772278.
Synonyms NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor NF-kappa-B p100 subunit; LYT 10; NF kB2; p52; p105; oncogene Lyt-10; DNA-binding factor KBF2; lymphocyte translocation chromosome 10 protein; nuclear fa
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NFKB2-1280H Recombinant Human NFKB2, GST-tagged E.coli GST
    Human NFKB2-306H Recombinant Human NFKB2 protein, His/MBP-tagged E.coli His/MBP
    Human NFKB2-4859 Recombinant Human NFKB2 protein, GST-tagged Insect Cell GST
    Human NFKB2-4859H Recombinant Human NFKB2, GST-tagged Sf9 Insect Cell GST
    Human NFKB2-7052H Recombinant Human NFKB2, GST-tagged Sf9 Insect Cell GST
    Human NFKB2-815H Recombinant Human NFKB2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Nfkb2-1851M Recombinant Mouse Nfkb2 protein, His & T7-tagged E.coli His/T7
    Chicken NFKB2-1850C Recombinant Chicken NFKB2 protein, His & T7-tagged E.coli His/T7
    Chicken NFKB2-5983C Recombinant Chicken NFKB2 Mammalian Cell His
    Zebrafish NFKB2-249Z Recombinant Zebrafish NFKB2 Mammalian Cell His

    nfkb2 involved in several pathways and played different roles in them. We selected most pathways nfkb2 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with nfkb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNB4A; NLK1; CACNA1DA; TGFBR1; MAPK12; FAS; FGF20B; FGF6A; CACNA2D4; RPS6KA6
    NF-kappa B signaling pathway CCL4L2; LYN; IL1B; ICAM1; CCL19; Bcl2a1b; TRAF5; LAT; IRAK4; SYK
    Osteoclast differentiation PIK3CA; SYK; IFNG; FOSL2; LILRA4; RELB; PPARG; cgr2b; PPP3R2; PIK3R1
    Legionellosis CASP8; CXCL3; EEF1A2; VCP; NFKBIA; HSPA6; CR1; SEC22B; RAB1B; ITGAM
    HTLV-I infection BUB3; STAT5B; BAX; LTA; ANAPC1; HLA-G; DVL2; PPP3R2; HLA-B; TP53INP1
    Epstein-Barr virus infection SNW1; MAPK11; TRAF2; PIK3CB; HSPA1B; HSPA2; POLR3K; POLR2A; POLR3F; PSMC6
    Pathways in cancer PIK3R5; PIK3CA; STAT3; ARAF; ITGA6; IGF1; GNG3; FZD10; Fasl; WNT11
    Viral carcinogenesis HDAC1; HIST1H4F; LYN; PIK3R1; CDK1; HDAC10; TBPL1; RANBP1; SYK; CREB3L2

    nfkb2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by nfkb2 itself. We selected most functions nfkb2 had, and list some proteins which have the same functions with nfkb2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ELF3; KLF5; NACC2; MAX; ZNF257; KCNA3; DDIT3; TCF3A; CUX2; EHF
    chromatin binding RING1; TRIM24; CBFA2T3; BAHCC1; KLF14; CHAF1B; RBPJ; MECP2; ZNF143; NKX2-5
    protein binding FUZ; NCBP1; NTRK1; AP2S1; AGPAT5; ARL13B; SCRN2; TOX4; CBX5; PDCD6IP
    transcription coactivator activity ELF3; TGFB1I1; TAF10; GTF2A2; NCOA2; NCOA1; FHL2; ENY2; YAP1; CD3D
    transcription factor activity, sequence-specific DNA binding TFCP2; ELK1; FOXG1; MNT; GRHL3; TAF13; RNF4; ALX3; FOXG1D; PLAGX
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ELF3; GABPA; PGR; FOXL2; ESRRA; IRF4; ZIC3; FOS; POU3F2; E2F4

    nfkb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with nfkb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of nfkb2.


    Lee, CE; Fulcher, DA; et al. Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. BLOOD 124:2964-2972(2014).
    Chen, K; Coonrod, EM; et al. Germline Mutations in NFKB2 Implicate the Noncanonical NF-kappa B Pathway in the Pathogenesis of Common Variable Immunodeficiency. AMERICAN JOURNAL OF HUMAN GENETICS 93:812-824(2013).

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy