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Official Full Name nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Background This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms NFKB1; p50; KBF1; p105; EBP-1; MGC54151; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; DKFZp686C01211; nuclearfactor NF-kappa-Bp105subunit; NF-kappabeta; OTTHUMP00000161765; OTTHUMP00000216418; OTTHUMP00000219572; DNA binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Nfkb1-4396M Recombinant Mouse Nfkb1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human NFKB1-5277H Recombinant Human NFKB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human NFKB1-105H Recombinant Human NFKB1 E.coli N/A
    Human NFKB1-120H Recombinant Human NFKB1 protein, T7/His-tagged E.coli T7/His
    Human NFKB1-1847H Recombinant Human NFKB1 protein, His & GST-tagged E.coli His/GST
    Human NFKB1-300H Recombinant Human NFKB1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human NFKB1-301H Recombinant Human NFKB1 protein, His/T7-tagged E.coli His/T7
    Human NFKB1-30382TH Recombinant Human NFKB1 Wheat Germ N/A
    Human NFKB1-30383TH Recombinant Human NFKB1 Wheat Germ N/A
    Human NFKB1-309H Recombinant Human NFKB1 protein, His/MBP-tagged E.coli His/MBP
    Human NFKB1-310H Recombinant Human NFKB1 protein, His/MBP-tagged E.coli His/MBP
    Human NFKB1-3850HCL Recombinant Human NFKB1 293 Cell Lysate HEK293 N/A
    Human NFKB1-633H Recombinant Human NFKB1, His-tagged Sf21 Insect Cell His
    Human NFKB1-85H Recombinant Human NFkB-p50 protein, active, GST-tagged E.coli GST
    Mouse NFKB1-10622M Recombinant Mouse NFKB1 Protein Mammalian Cell His
    Mouse Nfkb1-1848M Recombinant Mouse Nfkb1 protein, His & T7-tagged E.coli His/T7
    Rat Nfkb1-1849R Recombinant Rat Nfkb1 protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque NFKB1-3015R Recombinant Rhesus monkey NFKB1 Protein, His-tagged Mammalian Cell His
    Chicken NFKB1-1846C Recombinant Chicken NFKB1 protein, His & T7-tagged E.coli His/T7
    Chicken NFKB1-6691C Recombinant Chicken NFKB1 Mammalian Cell His

    nfkb1 involved in several pathways and played different roles in them. We selected most pathways nfkb1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with nfkb1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF6A; GNG12A; FGF20B; MAPK7; DUSP8A; MAPK12B; RAF1A; PPP3CCA; RRAS; RAF1B
    Ras signaling pathway RELA; KSR1; CDC42; FIGF; PLA2G12A; GNG2; NRAS; ZAP70; SHC2; RASA3
    cAMP signaling pathway HCN2; ARAP3; HCAR2; GABBR2; PIK3R2; ROCK2; HTR1B; CREB5; MAPK3; PDE4D
    Chemokine signaling pathway CCL14; CCL4; PIK3CG; PF4; PIK3CB; GNB1; CCL2; CXCL12; ARRB2; GRK6
    NF-kappa B signaling pathway IL-8; BCL2L1; TNF; CCL4L2; CFLAR; TRIM25; LCK; SYK; CCL19; MAP3K14
    HIF- signaling pathway HK2; LTBR; TF; RPS6KB2; PLCG1; PLCG2; IFNGR2; PRKCG; HKDC1; VHL
    Sphingolipid signaling pathway PIK3CG; SPTLC1; PPP2R3C; BDKRB2; ASAH1; PPP2R5C; PRKCG; NOS3; SGMS1; PPP2R5E
    PIK-Akt signaling pathway PHLPP1; PDGFC; TNC; VTN; STK11; ITGA2B; CREB3L2; PDGFRA; TCL1A; PGF
    Osteoclast differentiation CALCR; NFKB1; LILRB3; NCF2; FCGR1; CYBB; GAB2; NFATC2; PPP3CC; TGFB2
    Toll-like receptor signaling pathway IKBKB; TLR4; TLR7; IFNA8; CXCL11; RIPK1L; IFNA14; MAPK11; IFNPHI1; MAP2K4A
    NOD-like receptor signaling pathway TNFAIP3; MAPK8A; NFKBIAB; CASP8; HSP90B1; CARD9; ERBB2IP; MAP3K7; HSP90AA1; TRAF6
    RIG-I-like receptor signaling pathway IFNA2; RIPK1; TP-1; PIN1; NFKBIA; MAPK12B; TRADD; IFNW1; TANK; IFNB1
    Cytosolic DNA-sensing pathway CXCL10; POLR2H; PYCARD; IFNA12; POLR3E; CASPA; CCL4; POLR1C; NFKB1; POLR3GL
    T cell receptor signaling pathway NCK1; NCK2; CD8A; MAP3K14; NFATC1; PAK6; PIK3R5; AKT1; DBNLB; VAV3
    B cell receptor signaling pathway DOK3; LIME1; ARPC5; CD72; LILRB3; MAP2K1; PIK3R2; BTK; PRKCB; MAP4K1
    TNF signaling pathway Ccl12; MAP3K5; MAP2K6; MMP3; MAPK12; PIK3R1; RPS6KA5; MAP2K7; BCL3; IL15
    Neurotrophin signaling pathway NFKB1; CALM4; CAMK2D; AKT1; SH2B1; IRAK4; RIPK2; CALML3; YWHAE; TRAF6
    Prolactin signaling pathway SOCS3; PRL; FOS; PPIB; IRF1; NRAS; CCND1; GALT; ELF5; INS2
    Adipocytokine signaling pathway MAPK8A; TRAF2; PRKAG1; PRKAA1; TNFRSF1A; SOCS3; G6PC; PRKAG2; NPY; CPT1B
    Insulin resistance PIK3R3B; G6PC3; PPARGC1B; CREB3L3A; PTPN1; PPP1CB; G6PCA.2; GFPT2; SLC27A1A; RPS6KA3
    Non-alcoholic fatty liver disease (NAFLD) NDUFB10; NDUFS4; MLXIPL; SDHB; IL6; NDUFA5; MAPK8; LEP; NDUFA9; NDUFV2
    Cocaine addiction CDK5; GPSM1; CREB3L3; ATF4; GRIN2C; CREB3L2; PRKACG; PRKACA; NFKB1; GRIN1
    Epithelial cell signaling in Helicobacter pylori infection GIT1; ATP6V1C2; CDC42; ATP6V1H; ATP6V0D2; MAPK8; TCIRG1; NFKBIA; CXCR2; ATP6V1G2
    Shigellosis RHOG; SRC; CD44; MAPK3; UBE2D2; U2AF1; IL-8; ARPC5L; WASL; RIPK2
    Salmonella infection DYNC1I2A; ARPC5A; MAPK14B; LBP; RAC1; RAC1B; IL-8; IL8L2; KLC2; NOS2
    Pertussis MAPK10; FOS; C2; GNAI1; IRAK4; IL12A; Itgam&Itgb2; IRAK1; PYCARD; LY96
    Legionellosis CASP8; TNF; EEF1A2; NFKB2; NAIP7; TLR2; NAIP1; HSPA1L; CASP1; RELA
    Chagas disease (American trypanosomiasis) CCL3L3; MAPK1; PPP2R1A; PLCB4; CCL2; PIK3CB; TGFB3; IL1B2; CD247; AKT2
    Toxoplasmosis PIK3CD; TGFB3; TLR2; H2-AA; MAPK1; HSPA8; TAB2; MAPK3; IL10RA; IRGM1
    Amoebiasis LAMA5; TGFB3; C8G; IFNG; TGFB2; LAMC2; IL-8; COL5A2; SERPINB1A; PIK3R2
    Tuberculosis PIK3C3; Cd209g; TNF; MAPK13; IRAK1; ATP6V0A2; ITGAX; IFNA12; FCER1G; ITGAM
    Hepatitis C IFNA16; CLDN10; LDLR; CXCL8; CLDN9; MAVS; TRAF6; PIK3R2; RXRA; IFNA1
    Influenza A OAS2; CASP1; IFNA8; PIK3CB; HSPA8; NXF3; PIK3R3; MAVS; MAP2K2; PRSS2
    HTLV-I infection IL15; NFATC4; ITGB2L; WNT4; XBP1; LTA; Adcy4; HLA-C; VDAC3; IL1R1
    Herpes simplex infection IL12A; MHC2A; Ifna11; IFNA4; TNFRSF1A; PTPN11B; TAF6; TLR9; EIF2AK2; TAF5L
    Epstein-Barr virus infection HDAC5; IKBKG; AKT1; YWHAE; NEDD4; PIK3CD; POLR2J; EIF2AK2; TAB2; PSMD4
    Pathways in cancer LAMB3; CKS2; FGF20; FAS; EGLN2; HSP90B1; STAT5B; Fasl; TRAF6; GNA12
    Transcriptional misregulation in cancer HIST1H3F; MLF1; LRP2BP; FEV; ETV1; REL; PBX3; BCL2L1; PTK2; LDB1
    Viral carcinogenesis RELA; ATF4; HIST1H2BI; MAD1L1; HIST1H4D; STAT5B; HIST1H4K; PIK3R1; CCND2; GTF2H4
    MicroRNAs in cancer PIM1; NOTCH1; ERBB3; VIM; TP53; FSCN1; FOXP1; NOTCH2; SPRY2; TRP63
    Pancreatic cancer TGFB1; TP53; ARAF; PIK3R1; PIK3CD; TGFB3; RB1; CDC42; ARHGEF6; BCL2L1
    Prostate cancer PIK3R2; CREB5; SPINK1; TCF7L2; PTEN; FOXA1; GRB2; KRAS; SMARCD1; PIK3R5
    Chronic myeloid leukemia CRKL; IKBKB; GRB2; SHC4; SMAD3; CBLB; SHC3; TGFB1; CDK6; MAP2K2
    Acute myeloid leukemia IKBKG; PIK3R1; AKT2; PML; NRAS; STAT3; CEBPA; ARAF; RUNX1T1; MYC
    Small cell lung cancer ITGB1; PIK3R2; TRAF4; NFKB1; RARB; RELA; PIK3R5; ITGA3; PIK3CB; BIRC8
    Inflammatory bowel disease (IBD) IL21; STAT3; MAF; HLA-DRA; IL12B; HLA-DPB1; HLA-DRB5; IL12A; IL4R; IL6

    nfkb1 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by nfkb1 itself. We selected most functions nfkb1 had, and list some proteins which have the same functions with nfkb1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II distal enhancer sequence-specific DNA binding ARX; H3F3B; NFE2L1; MSC; ARID3B; NR5A1; PBX3; ESRRB; RXRB; NR2F6
    RNA polymerase II regulatory region sequence-specific DNA binding ZMYND11; FOXC1; ZNF548; PHOX2A; AIRE; GLIS1; CUX2; CSDA; PKNOX2; RELA
    actinin binding RELA; PKD2; NFKB1; TTN; PDLIM5; MICALL2; PROM1; CSRP3
    chromatin binding CEBPB; HINFP; SP100; CREB3; ATF2; YBX1; KDM8; SOX15; PHF8; NSBP1
    heat shock protein binding PPP5C; FKBP5; CDC37L1; DMPK; DNAJA3; DNAJC7; IRAK1; FKBP4; APAF1; TPR
    identical protein binding PDCD6; CORO1B; SH2B2; BAK1; TLR3; HSPB1; ABCD1; LCP1; CXADR; CEP72
    protein heterodimerization activity PEF1; HIST1H2BK; SOX5; ATF1; BOKB; CHRNA5; NOTCH1; LIFR; Itgam&Itgb2; UGT1A6A
    protein homodimerization activity VWF; OLIG2; TWIST1; MSH2; ZNF174; GPD1A; OLFM4; TENM2; GAMT; GRPEL2
    regulatory region DNA binding IRF3; IRF8; IRF6; IRF5; IRF2A; NFKB1; HMGA2; IRF1B; IRF1A; IRF4A
    transcription factor activity, sequence-specific DNA binding NOTCH1; TEAD1A; FOSL1; ZNF624; L3MBTL4; MAFGB; KDM1A; GRHL2; GATAD2B; SIX1A
    transcription factor binding EPN1; HDAC1; HES7; BRD7; DDIT3; SIX2; E2F5; DAXX; PPP1R13L; DNMT1
    transcription regulatory region DNA binding ZNF174; HIVEP2A; ZFP639; JUN; CCNT1; TP63; HNF1A; TP53; GABPA; SP1
    transcription regulatory region sequence-specific DNA binding SFPQ; TFAP2A; SOX11; SOX4; CRY2; NR5A1A; NR5A1B; SOX2; PSPC1; NFE2L3
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding HCFC1; MIXL1; FOXH1; TARDBP; BACH1; MEOX2; ARID3B; NFATC1; REL; HMGA1
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding FOXO3; PURB; ZEB1; HES6; ZC3H8; CDX2; ZBTB4; BCL6A; MSX2; BCL6

    nfkb1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with nfkb1 here. Most of them are supplied by our site. Hope this information will be useful for your research of nfkb1.

    MAP3K8; RELA

    Chen, Y; Lu, RQ; et al. The NFKB1 polymorphism (rs4648068) is associated with the cell proliferation and motility in gastric cancer. BMC GASTROENTEROLOGY 15:-(2015).
    Jacque, E; Schweighoffer, E; et al. IKK-induced NF-kappa B1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. JOURNAL OF EXPERIMENTAL MEDICINE 211:2085-2101(2014).

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