NFKB1
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Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
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Overview
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NFKB1; p50; KBF1; p105; EBP-1; MGC54151; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; DKFZp686C01211; nuclearfactor NF-kappa-Bp105subunit; NF-kappabeta; OTTHUMP00000161765; OTTHUMP00000216418; OTTHUMP00000219572; DNA binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Sf21 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|MBP
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- NFKB1 Related Signal Pathway
NFKB1 involved in several pathways and played different roles in them. We selected most pathways NFKB1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | IL1A;CACNA1SB;NFKB2;TRP53;PPP3CB;PRKACBB;MAPKAPK2;ELK4;PLA2G4D |
| Ras signaling pathway | GNB2;GRIN1;FGF14;RASA1;PLA2G5;RAB5B;FGF17;BAD;ABL2 |
| cAMP signaling pathway | PLD1;GRIN2D;CREB3L2;ATP2B4;PDE4B;HCN4;GNAI2;GRIA3;GRIN2B |
| Chemokine signaling pathway | SHC2;CCL28;LYN;VAV1;PLCB2;IKBKG;PIK3R1;CCL4;PF4V1 |
| NF-kappa B signaling pathway | LY96;TNFRSF1A;TRAF1;CXCL2;NFKB2;CCL21B;NFKBIA;TAB2;TRAF5 |
| HIF- signaling pathway | BCL2;TCEB1;Trf;MAP2K2;INS2;NOX3;PDHA1;PIK3CA;NOS2 |
| Sphingolipid signaling pathway | BAX;PLCB2;CERS5;FCER1G;LASS1;SMPD2;MAP2K1;PIK3R1;LASS4 |
| PIK-Akt signaling pathway | YWHAE;THBS4;EIF4E2;INS1;YWHAH;AKT2;GNGT2;RXRA;IFNAR1 |
| Apoptosis | BIDA;IL1B2;CASP3A;IRF6;PRKACAA;BCAP31;DCC;CASP4;DYNLL2 |
| Osteoclast differentiation | FYN;PIK3CB;PIK3CG;NCF1;IL1B;STAT1;MAP3K7;FOS;IL1A |
| Toll-like receptor signaling pathway | PIK3R2;SPP1;MAPK11;IFNA8;TLR2;IL8L2;IFNA4;PIK3R1;IRF3 |
| NOD-like receptor signaling pathway | PYCARD;NFKB1;NLRC4;Ccl12;HSP90AA1;CASP1;TRAF6;PSTPIP1A;IL1B |
| RIG-I-like receptor signaling pathway | ATG12;MAPK8A;IFNA8;AZI2;MAPK12A;IFNW1;DAK;CXCL10;MAPK12 |
| Cytosolic DNA-sensing pathway | IFNB;IFNA8;TBK1;IFNA5;IFNA10;POLR3GL;POLR3A;POLR2H;OSTN |
| T cell receptor signaling pathway | PIK3R5;PAK6;NFKBIA;PIK3CD;VAV1;MAPK11;PRKCQ;FOS;IL4 |
| B cell receptor signaling pathway | CARD11;MALT1;SLA2;PLEKHA1;PDK2B;IKBKG;MAP2K1;PDK2;TTC6 |
| TNF signaling pathway | NFKBIA;MAPK9;CREB5;CCL2;IL18R1;MAPK8;CXCL1;IKBKG;PIK3R3 |
| Neurotrophin signaling pathway | RAF1;PRKCD;PIK3CD;SORT1;FOXO3;RAC1;CALM2;IRS1;AKT2 |
| Prolactin signaling pathway | SHC3;MAPK12;TH;MAP2K2;PIK3R3;SOCS7;SHC2;CCND1;PPIB |
| Adipocytokine signaling pathway | SLC2A1A;SOCS3B;CAMKK1;PRKAG3B;JAK2A;ADIPOR2;AGRP;NFKBIAA;G6PC |
| Insulin resistance | G6PC;SLC2A4;PPP1CAB;ACACB;CREB3L1;SLC27A5;PRKAG2A;SLC2A1A;AKT3A |
| Non-alcoholic fatty liver disease (NAFLD) | PIK3R5;IL6;IRS1;PIK3CB;EIF2AK3;LEP;SOCS3;GSK3B;RELA |
| Cocaine addiction | GRIN3A;CDK5R1;ATF4;GRIN3B;CREB3L4;SLC6A3;SLC18A2;CREB3L3;GRM3 |
| Epithelial cell signaling in Helicobacter pylori infection | CXCR2;JAM2;MAPK13;JAM3;CDC42;PLCG1;ATP6V1G2;ATP6V0A4;ATP6V0E1 |
| Shigellosis | ELMO3;WASF1;NFKB1;PFN4;IKBKB;MAD2L2;ARPC5L;U2AF1L4;WASL |
| Salmonella infection | ROCK2;MAPK8;TLR5;RELA;CXCL8B.3;CDC42L;MAPK13;CD14;NOS2 |
| Pertussis | CD14;MAPK13;IRAK4;C1QA;GNAI1;NLRP3;GNAI3;C3;CASP1 |
| Legionellosis | IL18;TLR4;EEF1A1;RAB1;Itgam&Itgb2;RELA;RAB1A;HSPA1B;IL-8 |
| Leishmaniasis | HLA-DRA;FCGR1A;Itgam&Itgb2;C3;PRKCB;NCF1;HLA-DQA1;MAPK11;HLA-DRB3 |
| Chagas disease (American trypanosomiasis) | GNA14;PIK3R2;IL1B2;PIK3CB;GNAI2;PIK3CG;PPP2R1A;CASP8;IL12B |
| Toxoplasmosis | IFNG;TLR4;HLA-DMA;IL10RA;BIRC3;MAPK1;LAMB4;MAPK11;TLR2 |
| Amoebiasis | SERPINB9;RAB7A;IL1B;Itgam&Itgb2;SERPINB1B;LAMA4;COL4A4;SERPINB2;PIK3CD |
| Tuberculosis | TGFB2;CARD9;MAPK1;IFNA5;TLR2;CALM2;CYCS;RHOA;ATP6V0D1 |
| Hepatitis C | CLDN5;IRF9;MAPK9;IKBKE;NR1H3;PPP2R2C;IFNA1;PPP2R1B;IFNA6 |
| Hepatitis B | PRKCG;VDAC3;PTK2B;MMP9;EGR3;CASP9;STAT3;IFNA21;PIK3R1 |
| Measles | DDX58;CD3G;CD28;CD209;TNFRSF10D;TNFAIP3;STAT3;TLR2;Il2 |
| Influenza A | HSPA1B;IVNS1ABP;MAPK9;IFNA3;DNAJC3;PML;TYK2;PIK3R1;CXCL8 |
| HTLV-I infection | WNT8A;PIK3CD;TGFB3;RB1;TGFB1;Fzd4;PIK3CB;CDC20;WNT9A |
| Herpes simplex infection | TBK1;HMGN1;CFP;PPP1CBL;BMA1;PPP1CAB;SRSF1A;MHC2DCB;IFNA17 |
| Epstein-Barr virus infection | NCOR2;PIK3CD;HSPA2;CSNK2A2;HDAC5;POLR2J2;HDAC4;POLR2G;GTF2E2 |
| Pathways in cancer | GNG7;SMO;NKX3-1;PLEKHG5;NOS2;MMP2;RAC2;FGF8;RBX1 |
| Transcriptional misregulation in cancer | TP53;HPGD;IL-8;BIRC3;MEF2C;ASPSCR1;PAX8;CCND2;ETV6 |
| Viral carcinogenesis | HIST1H4L;RBPJ;PIK3CB;SRF;HIST1H4G;NFKB1;IKBKG;CCNA2;HDAC7A |
| MicroRNAs in cancer | ZEB1;TP53;FGFR3;NRAS;MMP9;SHC4;TNN;SERPINB5;GLS2 |
| Pancreatic cancer | BCL2L1;ERBB2;CCND1;RAD51;TGFBR2;TGFB3;AKT2;MAPK10;RALGDS |
| Prostate cancer | INSRR;IKBKG;MTOR;Ar;HRAS;PIK3R3;AKT2;BRAF;MAP2K2 |
| Chronic myeloid leukemia | TGFBR1;STAT5A;MAP2K2;GRB2;SHC3;RUNX1;GAB2;IKBKG;SHC2 |
| Acute myeloid leukemia | BAD;MAP2K1;AKT1;RELA;RUNX1T1;PPARD;AKT3;NRAS;MYC |
| Small cell lung cancer | XIAP;NFKBIA;TRAF2;LAMA1;CASP9;PIK3CG;APAF1;BIRC2;AKT1 |
| Inflammatory bowel disease (IBD) | HLA-DMA;IFNGR1;Il4ra;IFNG;STAT4;HLA-DOA;TGFB3;SMAD2;TBX21 |
NFKB1 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKB1 itself. We selected most functions NFKB1 had, and list some proteins which have the same functions with NFKB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II distal enhancer sequence-specific DNA binding | TFAP2C;PAX4;NFATC1;NR5A2;GZF1;MIXL1;FLI1;SPI1;T |
| RNA polymerase II regulatory region sequence-specific DNA binding | NEUROD2;DMBX1;NR1I3;ZNF792;RELB;NR1D1;TFAP2D;ZFY1;LMO2 |
| actinin binding | TTN;PROM1;CSRP3;NFKB1;PDLIM5;MICALL2;RELA;PKD2 |
| chromatin binding | ATXN7;CAPNS2;HHEX;MEOX1;BRD2;RFX4;SP3;ESR1;TAF2 |
| heat shock protein binding | PARK2;SSUH2RS1;TOMM34;CDC37;HSPA1B;FKBP5;BCOR;HDAC2;DNAJC7 |
| identical protein binding | MAPK1IP1;PLDN;PTEN;LYZ1;AGXT2L2;TPCN1;LECT2;ST13;DNMT3A |
| protein binding | GSTM4;FAM156A;DSC2;PCGF1;CARD11;ATP6V1H;CPSF7;LIMS3L;RNF146 |
| protein heterodimerization activity | HIST3H2BB;TLR2;HIF1A;MEIS1;HER11;CLNS1A;YWHAE;SMAD3;RXRA |
| protein homodimerization activity | TCF3;RAG1;SLC30A8;QPRT;VEGFA;ABCD1;DCK;GZMA;CITED1 |
| regulatory region DNA binding | IRF6;IRF2A;HMGA2;IRF1A;IRF4A;NFKB1;IRF3;IRF1B;IRF8 |
| transcription factor activity, sequence-specific DNA binding | MXD1;E2F1;TFAP2B;RARAB;SIM1;SCML1;ZKSCAN4;TRPS1;MESPBA |
| transcription factor binding | PPRC1;STAT3;ARHGEF2;EGR1;FOSB;CREBBP;HES2;NFIA;GATA3 |
| transcription regulatory region DNA binding | WNT5A;SMAD6;ETV5;CBX4;XRCC5;CREB3L1;IKZF3;GLI1;RFX3 |
| transcription regulatory region sequence-specific DNA binding | HIF1AL;PSPC1;PER2;SFPQ;SIN3A;SOX2;FOXJ1;NR5A2;KDM3A |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | PBX3;SUB1;RELA;HMGA1;SIX3;HOXB5;SPI1;ARID3B;REL |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | SATB1;ZBTB12.2;JARID2;NFKB1;FOXD3;BCL6;ZNF350;ZC3H8;ISX |
NFKB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKB1.
MAP3K8; RELA
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Customer Reviews (3)
Write a reviewPotent biological activity of NFKB1, combined with its high purity, provides accurate and reliable experimental data for the research field.
The short half-life and high clearance of NFKB1 allow its rapid action and rapid clearance in vivo, improving therapeutic efficiency.
Beacuse production process of NFKB1 realizes the minimization of waste and the minimal impact on the environment, which is truly green production.
Q&As (6)
Ask a questionNFKB1 protein is involved in the occurrence and progression of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.
NFKB1 protein plays a complex role in apoptosis and may promote or inhibit the occurrence of apoptosis.
A variety of drugs have been developed that target the NFKB1 protein and its downstream signaling pathways, such as inhibiting NFKB1 activation or inhibiting the transcriptional activity of NFKB1 downstream genes.
The protein plays a key role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of NFKB1 protein will help the development of new drugs, such as targeted drugs targeting NFKB1 protein and its signaling pathway may be applied to the treatment of related diseases.
This protein plays an important role in the activation of immune cells and the regulation of inflammation, so it can be used in immune vaccine design to enhance immune effects.
The expression pattern of NFKB1 protein in immune cells is regulated by different stimuli and environments, and participates in the activation and regulation of immune cells.
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