NFKB1

  • Official Full Name

    nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

  • Overview

    This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    NFKB1; p50; KBF1; p105; EBP-1; MGC54151; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; DKFZp686C01211; nuclearfactor NF-kappa-Bp105subunit; NF-kappabeta; OTTHUMP00000161765; OTTHUMP00000216418; OTTHUMP00000219572; DNA binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Sf21 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NFKB1-30382TH Recombinant Human NFKB1 Wheat Germ N/A 110 amino acids
Human NFKB1-120H Recombinant Human NFKB1 protein, T7/His-tagged E.coli T7/His
Human NFKB1-105H Recombinant Human NFKB1 E.coli N/A
Human NFKB1-30383TH Recombinant Human NFKB1 Wheat Germ N/A 968 amino acids
Human NFKB1-85H Recombinant Human NFkB-p50 protein, active, GST-tagged E.coli GST
Human NFKB1-300H Recombinant Human NFKB1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NFKB1-301H Recombinant Human NFKB1 protein, His/T7-tagged E.coli His/T7
Human NFKB1-633H Recombinant Human NFKB1, His-tagged Sf21 Insect Cell His
Human NFKB1-309H Recombinant Human NFKB1 protein, His/MBP-tagged E.coli His/MBP 1-135 aa
Human NFKB1-310H Recombinant Human NFKB1 protein, His/MBP-tagged E.coli His/MBP 757-969 aa
Human NFKB1-1847H Recombinant Human NFKB1 protein, His & GST-tagged E.coli His/GST Gln805~Ser892 (Accession # P19838)
Human NFKB1-3850HCL Recombinant Human NFKB1 293 Cell Lysate HEK293 N/A
Human NFKB1-3973H Recombinant Human NFKB1 protein, His-tagged E.coli His 1-368 aa
Human NFKB1-4689H Recombinant Human NFKB1 Protein (Asp40-Tyr349), N-His tagged E.coli N-His Asp40-Tyr349
Human NFKB1-106H Recombinant Human NFKB1(Met1-Gly434) Protein, N-6*His-tagged E.coli His
Human NFKB1-5277H Recombinant Human NFKB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NFKB1-3742H Recombinant Human NFKB1 protein, GST-tagged E.coli GST 1-368 aa
Human NFKB1-4690H Recombinant Human NFKB1 Protein (Met1-Ile969), N-His tagged E.coli N-His Met1-Ile969
Human NFKB1-343HF Recombinant Full Length Human NFKB1 Protein In Vitro Cell Free System 968 amino acids
Human NFKB1-5260H Recombinant Human NFKB1 protein, GST-tagged E.coli GST 1-968aa
Human NFKB1-6931HFL Recombinant Full Length Human NFKB1 protein, Flag-tagged Mamanlian cells Flag
Human NFKB1-2816H Recombinant Human NFKB1 Protein (Met248-Ile366), His tagged E.coli His Met248-Ile366
Mouse Nfkb1-1848M Recombinant Mouse Nfkb1 protein, His & T7-tagged E.coli His/T7 Pro40~Met365
Mouse NFKB1-10622M Recombinant Mouse NFKB1 Protein Mammalian Cell His
Mouse NFKB1-6038M-B Recombinant Mouse NFKB1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Nfkb1-4396M Recombinant Mouse Nfkb1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NFKB1-6038M Recombinant Mouse NFKB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Nfkb1-1849R Recombinant Rat Nfkb1 protein, His & GST-tagged E.coli His/GST Gln352~Phe439 (Accession # Q63369)
Cattle NFKB1-2487C Recombinant Cattle NFKB1 Protein, His-tagged E.coli N-His Ala2-Glu295
Rhesus Macaque NFKB1-3015R Recombinant Rhesus monkey NFKB1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NFKB1-2834R-B Recombinant Rhesus Macaque NFKB1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NFKB1-2834R Recombinant Rhesus Macaque NFKB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken NFKB1-1846C Recombinant Chicken NFKB1 protein, His & T7-tagged E.coli His/T7 Pro47~Met372 (Accession # Q04861)
Chicken NFKB1-6691C Recombinant Chicken NFKB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • NFKB1 Related Signal Pathway

NFKB1 involved in several pathways and played different roles in them. We selected most pathways NFKB1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayIL1A;CACNA1SB;NFKB2;TRP53;PPP3CB;PRKACBB;MAPKAPK2;ELK4;PLA2G4D
Ras signaling pathwayGNB2;GRIN1;FGF14;RASA1;PLA2G5;RAB5B;FGF17;BAD;ABL2
cAMP signaling pathwayPLD1;GRIN2D;CREB3L2;ATP2B4;PDE4B;HCN4;GNAI2;GRIA3;GRIN2B
Chemokine signaling pathwaySHC2;CCL28;LYN;VAV1;PLCB2;IKBKG;PIK3R1;CCL4;PF4V1
NF-kappa B signaling pathwayLY96;TNFRSF1A;TRAF1;CXCL2;NFKB2;CCL21B;NFKBIA;TAB2;TRAF5
HIF- signaling pathwayBCL2;TCEB1;Trf;MAP2K2;INS2;NOX3;PDHA1;PIK3CA;NOS2
Sphingolipid signaling pathwayBAX;PLCB2;CERS5;FCER1G;LASS1;SMPD2;MAP2K1;PIK3R1;LASS4
PIK-Akt signaling pathwayYWHAE;THBS4;EIF4E2;INS1;YWHAH;AKT2;GNGT2;RXRA;IFNAR1
ApoptosisBIDA;IL1B2;CASP3A;IRF6;PRKACAA;BCAP31;DCC;CASP4;DYNLL2
Osteoclast differentiationFYN;PIK3CB;PIK3CG;NCF1;IL1B;STAT1;MAP3K7;FOS;IL1A
Toll-like receptor signaling pathwayPIK3R2;SPP1;MAPK11;IFNA8;TLR2;IL8L2;IFNA4;PIK3R1;IRF3
NOD-like receptor signaling pathwayPYCARD;NFKB1;NLRC4;Ccl12;HSP90AA1;CASP1;TRAF6;PSTPIP1A;IL1B
RIG-I-like receptor signaling pathwayATG12;MAPK8A;IFNA8;AZI2;MAPK12A;IFNW1;DAK;CXCL10;MAPK12
Cytosolic DNA-sensing pathwayIFNB;IFNA8;TBK1;IFNA5;IFNA10;POLR3GL;POLR3A;POLR2H;OSTN
T cell receptor signaling pathwayPIK3R5;PAK6;NFKBIA;PIK3CD;VAV1;MAPK11;PRKCQ;FOS;IL4
B cell receptor signaling pathwayCARD11;MALT1;SLA2;PLEKHA1;PDK2B;IKBKG;MAP2K1;PDK2;TTC6
TNF signaling pathwayNFKBIA;MAPK9;CREB5;CCL2;IL18R1;MAPK8;CXCL1;IKBKG;PIK3R3
Neurotrophin signaling pathwayRAF1;PRKCD;PIK3CD;SORT1;FOXO3;RAC1;CALM2;IRS1;AKT2
Prolactin signaling pathwaySHC3;MAPK12;TH;MAP2K2;PIK3R3;SOCS7;SHC2;CCND1;PPIB
Adipocytokine signaling pathwaySLC2A1A;SOCS3B;CAMKK1;PRKAG3B;JAK2A;ADIPOR2;AGRP;NFKBIAA;G6PC
Insulin resistanceG6PC;SLC2A4;PPP1CAB;ACACB;CREB3L1;SLC27A5;PRKAG2A;SLC2A1A;AKT3A
Non-alcoholic fatty liver disease (NAFLD)PIK3R5;IL6;IRS1;PIK3CB;EIF2AK3;LEP;SOCS3;GSK3B;RELA
Cocaine addictionGRIN3A;CDK5R1;ATF4;GRIN3B;CREB3L4;SLC6A3;SLC18A2;CREB3L3;GRM3
Epithelial cell signaling in Helicobacter pylori infectionCXCR2;JAM2;MAPK13;JAM3;CDC42;PLCG1;ATP6V1G2;ATP6V0A4;ATP6V0E1
ShigellosisELMO3;WASF1;NFKB1;PFN4;IKBKB;MAD2L2;ARPC5L;U2AF1L4;WASL
Salmonella infectionROCK2;MAPK8;TLR5;RELA;CXCL8B.3;CDC42L;MAPK13;CD14;NOS2
PertussisCD14;MAPK13;IRAK4;C1QA;GNAI1;NLRP3;GNAI3;C3;CASP1
LegionellosisIL18;TLR4;EEF1A1;RAB1;Itgam&Itgb2;RELA;RAB1A;HSPA1B;IL-8
LeishmaniasisHLA-DRA;FCGR1A;Itgam&Itgb2;C3;PRKCB;NCF1;HLA-DQA1;MAPK11;HLA-DRB3
Chagas disease (American trypanosomiasis)GNA14;PIK3R2;IL1B2;PIK3CB;GNAI2;PIK3CG;PPP2R1A;CASP8;IL12B
ToxoplasmosisIFNG;TLR4;HLA-DMA;IL10RA;BIRC3;MAPK1;LAMB4;MAPK11;TLR2
AmoebiasisSERPINB9;RAB7A;IL1B;Itgam&Itgb2;SERPINB1B;LAMA4;COL4A4;SERPINB2;PIK3CD
TuberculosisTGFB2;CARD9;MAPK1;IFNA5;TLR2;CALM2;CYCS;RHOA;ATP6V0D1
Hepatitis CCLDN5;IRF9;MAPK9;IKBKE;NR1H3;PPP2R2C;IFNA1;PPP2R1B;IFNA6
Hepatitis BPRKCG;VDAC3;PTK2B;MMP9;EGR3;CASP9;STAT3;IFNA21;PIK3R1
MeaslesDDX58;CD3G;CD28;CD209;TNFRSF10D;TNFAIP3;STAT3;TLR2;Il2
Influenza AHSPA1B;IVNS1ABP;MAPK9;IFNA3;DNAJC3;PML;TYK2;PIK3R1;CXCL8
HTLV-I infectionWNT8A;PIK3CD;TGFB3;RB1;TGFB1;Fzd4;PIK3CB;CDC20;WNT9A
Herpes simplex infectionTBK1;HMGN1;CFP;PPP1CBL;BMA1;PPP1CAB;SRSF1A;MHC2DCB;IFNA17
Epstein-Barr virus infectionNCOR2;PIK3CD;HSPA2;CSNK2A2;HDAC5;POLR2J2;HDAC4;POLR2G;GTF2E2
Pathways in cancerGNG7;SMO;NKX3-1;PLEKHG5;NOS2;MMP2;RAC2;FGF8;RBX1
Transcriptional misregulation in cancerTP53;HPGD;IL-8;BIRC3;MEF2C;ASPSCR1;PAX8;CCND2;ETV6
Viral carcinogenesisHIST1H4L;RBPJ;PIK3CB;SRF;HIST1H4G;NFKB1;IKBKG;CCNA2;HDAC7A
MicroRNAs in cancerZEB1;TP53;FGFR3;NRAS;MMP9;SHC4;TNN;SERPINB5;GLS2
Pancreatic cancerBCL2L1;ERBB2;CCND1;RAD51;TGFBR2;TGFB3;AKT2;MAPK10;RALGDS
Prostate cancerINSRR;IKBKG;MTOR;Ar;HRAS;PIK3R3;AKT2;BRAF;MAP2K2
Chronic myeloid leukemiaTGFBR1;STAT5A;MAP2K2;GRB2;SHC3;RUNX1;GAB2;IKBKG;SHC2
Acute myeloid leukemiaBAD;MAP2K1;AKT1;RELA;RUNX1T1;PPARD;AKT3;NRAS;MYC
Small cell lung cancerXIAP;NFKBIA;TRAF2;LAMA1;CASP9;PIK3CG;APAF1;BIRC2;AKT1
Inflammatory bowel disease (IBD)HLA-DMA;IFNGR1;Il4ra;IFNG;STAT4;HLA-DOA;TGFB3;SMAD2;TBX21

NFKB1 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKB1 itself. We selected most functions NFKB1 had, and list some proteins which have the same functions with NFKB1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II distal enhancer sequence-specific DNA bindingTFAP2C;PAX4;NFATC1;NR5A2;GZF1;MIXL1;FLI1;SPI1;T
RNA polymerase II regulatory region sequence-specific DNA bindingNEUROD2;DMBX1;NR1I3;ZNF792;RELB;NR1D1;TFAP2D;ZFY1;LMO2
actinin bindingTTN;PROM1;CSRP3;NFKB1;PDLIM5;MICALL2;RELA;PKD2
chromatin bindingATXN7;CAPNS2;HHEX;MEOX1;BRD2;RFX4;SP3;ESR1;TAF2
heat shock protein bindingPARK2;SSUH2RS1;TOMM34;CDC37;HSPA1B;FKBP5;BCOR;HDAC2;DNAJC7
identical protein bindingMAPK1IP1;PLDN;PTEN;LYZ1;AGXT2L2;TPCN1;LECT2;ST13;DNMT3A
protein bindingGSTM4;FAM156A;DSC2;PCGF1;CARD11;ATP6V1H;CPSF7;LIMS3L;RNF146
protein heterodimerization activityHIST3H2BB;TLR2;HIF1A;MEIS1;HER11;CLNS1A;YWHAE;SMAD3;RXRA
protein homodimerization activityTCF3;RAG1;SLC30A8;QPRT;VEGFA;ABCD1;DCK;GZMA;CITED1
regulatory region DNA bindingIRF6;IRF2A;HMGA2;IRF1A;IRF4A;NFKB1;IRF3;IRF1B;IRF8
transcription factor activity, sequence-specific DNA bindingMXD1;E2F1;TFAP2B;RARAB;SIM1;SCML1;ZKSCAN4;TRPS1;MESPBA
transcription factor bindingPPRC1;STAT3;ARHGEF2;EGR1;FOSB;CREBBP;HES2;NFIA;GATA3
transcription regulatory region DNA bindingWNT5A;SMAD6;ETV5;CBX4;XRCC5;CREB3L1;IKZF3;GLI1;RFX3
transcription regulatory region sequence-specific DNA bindingHIF1AL;PSPC1;PER2;SFPQ;SIN3A;SOX2;FOXJ1;NR5A2;KDM3A
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingPBX3;SUB1;RELA;HMGA1;SIX3;HOXB5;SPI1;ARID3B;REL
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific bindingSATB1;ZBTB12.2;JARID2;NFKB1;FOXD3;BCL6;ZNF350;ZC3H8;ISX

NFKB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKB1.

MAP3K8; RELA

Research Area

Related articles

Chen, Y; Lu, RQ; et al. The NFKB1 polymorphism (rs4648068) is associated with the cell proliferation and motility in gastric cancer. BMC GASTROENTEROLOGY 15:-(2015).
Jacque, E; Schweighoffer, E; et al. IKK-induced NF-kappa B1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. JOURNAL OF EXPERIMENTAL MEDICINE 211:2085-2101(2014).
  • Q&As
  • Reviews

Q&As (6)

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What is the role of NFKB1 protein in autoimmune diseases? 10/17/2019

NFKB1 protein is involved in the occurrence and progression of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.

What is the relationship between NFKB1 protein and apoptosis? 08/15/2019

NFKB1 protein plays a complex role in apoptosis and may promote or inhibit the occurrence of apoptosis.

What drugs interact with the NFKB1 protein? 04/16/2019

A variety of drugs have been developed that target the NFKB1 protein and its downstream signaling pathways, such as inhibiting NFKB1 activation or inhibiting the transcriptional activity of NFKB1 downstream genes.

Does the NFKB1 protein study have implications for new drug development? 03/01/2019

The protein plays a key role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of NFKB1 protein will help the development of new drugs, such as targeted drugs targeting NFKB1 protein and its signaling pathway may be applied to the treatment of related diseases.

Is there a potential application of NFKB1 protein in the design of immune vaccines? 01/18/2019

This protein plays an important role in the activation of immune cells and the regulation of inflammation, so it can be used in immune vaccine design to enhance immune effects.

Why does NFKB1 protein have a pattern of expression in immune cells? 01/17/2019

The expression pattern of NFKB1 protein in immune cells is regulated by different stimuli and environments, and participates in the activation and regulation of immune cells.

Customer Reviews (3)

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Reviews
06/16/2022

    Potent biological activity of NFKB1, combined with its high purity, provides accurate and reliable experimental data for the research field.

    04/22/2022

      The short half-life and high clearance of NFKB1 allow its rapid action and rapid clearance in vivo, improving therapeutic efficiency.

      05/21/2019

        Beacuse production process of NFKB1 realizes the minimization of waste and the minimal impact on the environment, which is truly green production.

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