Recombinant Human Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64), AVI-tagged
Cat.No. : | FCGR1A-3818H |
Product Overview : | A DNA sequence encoding the extracellular domain of human CD64 ( NP_000557.1 ) ( Met 1 - Thr 287 ) was fused with a C-terminal polyhistidine tagged AVI tag at the C-terminus The expressed protein was biotinylated in vivo by the Biotin-Protein ligase ( BirA enzyme ) which is co-expressed. |
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Cat. No. : | FCGR1A-3818H |
Description : | High affinity immunoglobulin gamma Fc receptor IA , also known as IgG Fc receptor IA (FCGR1A) and CD64, is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity. CD64 belongs to the immunoglobulin superfamily. It is structurally composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. |
Source : | Human |
Host : | Human Cells |
Form : | Lyophilized from sterile PBS , pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Purity : | > 95 % as determined by SDS-PAGE |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Stability : | Samples are stable for up to twelve months from date of receipt at -70°C. |
Predicted N terminal : | Gln 16 |
Molecular Mass : | The secreted recombinant human CD64 consists of 307 amino acids and has a predicted molecular mass of 34.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCD64 is approximately 50-55 kDa due to glycosylation. |
Storage : | Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) [ Homo sapiens ] |
Official Symbol : | FCGR1A |
Synonyms : | FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64); CD64; FCRI; CD64A; IGFR1; FLJ18345; FCGR1A; high affinity immunoglobulin gamma Fc receptor I; fcgammaRIa; Fc-gamma RI; fc-gamma RIA; Fc gamma receptor; IgG Fc receptor I; Fc-gamma receptor I A1; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FcRI; CD64 antigen |
Gene ID : | 2209 |
mRNA Refseq : | NM_000566 |
Protein Refseq : | NP_000557 |
MIM : | 146760 |
UniProt ID : | P12314 |
Chromosome Location : | 1q21.2-q21.3 |
Pathway : | Fc gamma R-mediated phagocytosis; Hematopoietic cell lineage; Leishmania infection; Systemic lupus erythematosus |
Function : | receptor signaling protein activity; IgG binding; protein binding; receptor activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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