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FCGR2A

  • Official Full Name

    Fc fragment of IgG, low affinity IIa, receptor (CD32)

  • Overview

    This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.
  • Synonyms

    FCGR2A; Fc fragment of IgG, low affinity IIa, receptor (CD32); CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • Cynomolgus
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse myeloma cell
  • Wheat Germ
  • C
  • His
  • Fc
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|Avi
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FCGR2A-1134H Active Recombinant Human FCGR2A protein, His-tagged HEK293 His Met1-Ile218,167Arg
Human FCGR2A-649H Active Recombinant Human FCGR2A protein(167 Arg), His-tagged HEK293 His Met1-Ile218
Human FCGR2A-2963H Active Recombinant Human FCGR2A, His & AVI Tagged, Biotinylated, 167 His Human Cell His/Avi Met1-Met210
Human FCGR2A-260H Active Recombinant Human FCGR2A Protein, His-tagged, Biotinylated HEK293 His
Human FCGR2A-352H Active Recombinant Human FCGR2A protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Ala 35 - Ile 217
Human FCGR2A-161H Active Recombinant Human FCGR2A, His-tagged Mammalian cells His
Human FCGR2A-12819H Recombinant Human FCGR2A, GST-tagged E.coli GST 39-220a.a.
Human FCGR2A-3992H Recombinant Human FCGR2A Protein, GST-tagged Wheat Germ GST
Human FCGR2A-399H Active Recombinant Human FCGR2A protein, His-tagged CHO His Met1-Ile218,167H
Human FCGR2A-3990H Recombinant Human FCGR2A Protein Wheat Germ N/A
Human FCGR2A-1136H Recombinant Human FCGR2A, His & AVI tagged Human Cell His/Avi
Human FCGR2A-7236H Recombinant Human FCGR2A, His-tagged E.coli His 34-216aa
Human FCGR2A-259H Recombinant Human FCGR2A, His-tagged, Biotinylated HEK293 His
Human FCGR2A-3130H Active Recombinant Human FCGR2A protein, hFc-tagged HEK293 hFc Met1-Ile218, 167Arg
Human FCGR2A-2964H Recombinant Human FCGR2A, His & AVI Tagged, Biotinylated, 167 Arg Human Cell His/Avi Met1-Met210
Human FCGR2A-3074H Recombinant Human FCGR2A, His tagged Insect Cell His
Human FCGR2A-001HCL Recombinant Human FCGR2A cell lysate CHO N/A
Human FCGR2A-678HCL Recombinant Human FCGR2A cell lysate Insect Cell N/A
Human FCGR2A-1996HCL Recombinant Human FCGR2A cell lysate Human Cell N/A
Human FCGR2A-383H Active Recombinant Human FCGR2A protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala36-Ile218
Human FCGR2A-333H Recombinant Human FCGR2A(H167) protein, His-Avi-tagged HEK293 His-Avi It contains Ala 36 - Ile 218 (H167).
Human FCGR2A-4738HF Recombinant Full Length Human FCGR2A Protein In Vitro Cell Free System 542 amino acids
Human FCGR2A-384H Active Recombinant Human FCGR2A Protein (R167) (Ala 36 - Ile 218), His & Avi-tagged, Biotinylated HEK293 His/Avi Ala 36 - Ile 218
Human FCGR2A-3548H Active Recombinant Human FCGR3A protein(R167), His-tagged HEK293 His Gln34-Ile218
Human FCGR2A-513HB Recombinant Human FCGR2A protein(F176), His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Gly17-Gln208 (F176).
Human FCGR2A-041H Recombinant Human FCGR2A Protein, ECD, Tag Free, Biotinylated HEK293 Tag Free ECD
Human FCGR2A-06H Active Recombinant Human FCGR2A Protein, His-tagged Mouse myeloma cell His
Human FCGR2A-542H Recombinant Human FCGR2A Protein (R167) HEK293 317
Human FCGR2A-1225HFL Recombinant Full Length Human FCGR2A Protein, C-Flag-tagged Mammalian cells Flag
Human FCGR2A-313HB Recombinant Human FCGR2A protein(V176), His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Gly17-Gln208 .
Human FCGR2A-899H Recombinant Human FCGR2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FCGR2A-543H Recombinant Human FCGR2A Protein (H167) HEK293 317
Human FCGR2A-17H Active Recombinant Human FCGR2A (R167H) Protein (30-218aa), C-His-tagged HEK293 C-His 30-218 aa
Human FCGR2A-899H-B Recombinant Human FCGR2A Protein Pre-coupled Magnetic Beads HEK293
Human FCGR2A-301H Recombinant Human FCGR2A Protein, His-tagged HEK293 His 317
Human FCGR2A-2764H Recombinant Human FCGR2A Protein (Ala36-Ile218), C-His tagged Mammalian cells C-His Ala36-Ile218
Human FCGR2A-2618H Active Recombinant Human FCGR2A protein, His-tagged HEK293 His Ala36-Ile218 (R167)
Human FCGR2A-1126H Recombinant Human FCGR2A Protein (Gln34-Asn316), N-His tagged E.coli N-His Gln34-Asn316
Human FCGR2A-4108H Recombinant Human FCGR2A Protein (Met1-Ile218), C-His tagged Mammalian cells C-His Met1-Ile218
Mouse FCGR2A-643M Active Recombinant Mouse FCGR2A protein, His-Avi-tagged HEK293 His-Avi Gln34-Leu216
Rat FCGR2A-2305R Recombinant Rat FCGR2A Protein Mammalian Cell His
Rat Fcgr2a-4939R Recombinant Rat Fcgr2a protein, Fc-tagged HEK293 Fc Met1-Leu216
Rat FCGR2A-1962R Recombinant Rat FCGR2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FCGR2A-1962R-B Recombinant Rat FCGR2A Protein Pre-coupled Magnetic Beads HEK293
Rat FCGR2A-932R Recombinant Rat FCGR2A Protein (Met1-Leu216), His-tagged HEK293 His Met1-Leu216
Cynomolgus FCGR2A-1472C Active Recombinant Cynomolgus FCGR2A protein, His-tagged HEK293 His Gln28-Pro208
Cynomolgus FCGR2A-568C Active Recombinant Cynomolgus FCGR2A protein, His-Avi-tagged HEK293 His-Avi Gln28-Pro208
Cynomolgus FCGR2A-1473C Active Recombinant Cynomolgus FCGR2A protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln28-Pro208
Cynomolgus FCGR2A-297C Active Recombinant Cynomolgus FCGR2A protein, His/Avi-tagged, Biotinylated HEK293 His/Avi Met 1-Gly 220
Cynomolgus Monkey FCGR2A-270C Active Recombinant Cynomolgus Monkey FCGR2A protein, His-tagged HEK293 His
Cynomolgus Monkey FCGR2A-519C Recombinant Cynomolgus FCGR2A Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey FCGR2A-2973C Recombinant Cynomolgus FCGR2A, His & AVI tagged Human Cell His/Avi
Cynomolgus Monkey FCGR2A-4108C Recombinant Cynomolgus Fc Fragment Of LgG, Low Affinity LIa, Receptor (CD32), AVI-tagged Cynomolgus N/A
Cynomolgus Monkey FCGR2A-4107C Recombinant Cynomolgus FCGR2A, His tagged Human Cell His
Cynomolgus Monkey FCGR2A-1926CCL Recombinant Cynomolgus FCGR2A cell lysate Human Cell N/A
Cynomolgus Monkey FCGR2A-264C Recombinant Cynomolgus Monkey FCGR2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey FCGR2A-264C-B Recombinant Cynomolgus Monkey FCGR2A Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL9733HF Recombinant Full Length Human Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-A(Fcgr2A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (34-317)
Rhesus Macaque FCGR2A-4111C Active Recombinant Rhesus FCGR2A protein, His-tagged HEK293 His Met 1-Ile 217
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FCGR2A Related Articles
FCGR2A-7.jpg

Fig1. FCGR2A-related protein interaction network. (Yongmei Dai, 2021)

What is FCGR2A protein?

FCGR2A (Fc gamma receptor IIa) gene is a protein coding gene which situated on the long arm of chromosome 1 at locus 1q23. This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The FCGR2A protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. FCGR2A is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. This protein is consisted of 317 amino acids and is approximately 35 kDa.

What is the Function of FCGR2A protein?

Associated with an ITAM (immunoreceptor tyrosine-based activation motif)- bearing adapter subunit, FCGR2A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. It can also bind to IgG antibodies to promote the phagocytosis and destruction of immune cells (such as monocytes, macrophages, and dendritic cells) against pathogens or foreign bodies labeled by antibodies, thereby enhancing antibody-mediated cytotoxicity.

FCGR2A Related Signaling Pathway

When FCGR2A binds to the Fc part of IgG antibody, it activates the downstream signaling pathway through the ITAM region in its cytoplasm. These signaling pathways, including Syk tyrosine kinase, PI3K/Akt, NF-κB, etc., regulate the activation, proliferation, and inflammatory response of macrophages, dendritic cells, and B cells.

FCGR2A Related Diseases

FCGR2A gene mutation may lead to the occurrence of autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus and so on. It may also lead to the occurrence of allergic diseases, such as asthma and allergic rhinitis. Other research reports FCGR2A functional genetic variant is associated with susceptibility to severe malarial anaemia in Ghanaian children.

Bioapplications of FCGR2A

The anti-ige antibody drug Omalizumab inhibits the FCGR2A signaling pathway by binding to IgE antibodies, thereby reducing allergic reactions. At the same time, some studies are exploring the use of gene editing technology to change the expression level of FCGR2A in order to achieve better immunomodulatory effects.

High Purity

High Bioactivity

FCGR2A-2.jpg

Fig2. Activity Data. (FCGR2A-333H)

Case Study 1: Wei Liao, 2023

FCGR2A-3.jpg

Fig1. Immunofluorescence staining detected expression of key genes in PC12 and H9c2 cells and hypoxia-reoxygenated cell models (bar = 50 μm).

Case Study 2: Xin Zhao, 2021

FCGR2A-4.jpg

Fig2. The expression of EREG, FCGR2A, CCL4L2, and CTSC increases from the normal pancreas to PASC.

FCGR2A-5.jpg

Fig1. DDP downregulated the expression of FCGR2A, thus inhibiting the conversion of pyruvate to lactate and lowering the energy metabolism in tumor cells. (Suxing Jin, 2023)

FCGR2A-6.jpg

Fig2. Model of potential impacts of Kawasaki disease (KD) associated genetic variants PELI1, ITPKC, FCGR2A, and genetic polymorphisms in STING and STAT3 on TLR/inflammasome/IFN dysregulation, which might lead to predisposition to COVID-19 related MIS-C. (Chin-An Yang, 2022)

FCGR2A involved in several pathways and played different roles in them. We selected most pathways FCGR2A participated on our site, such as Phagosome, Osteoclast differentiation, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeATP6V0A4;Cd209g;RAC1A;TUBA1A;ATP6V0CA;BF1;THBS3;SEC61AL2;FCGR3
Osteoclast differentiationPPP3R1;MAPK8;MAP2K1;FCGR1;cgr2b;LCK;AKT2;IFNGR2;MAPK10
Platelet activationPLCB3;F2R;ARHGAP35;ARHGEF12;STIM1;ITGB3;GNAS;SYK;AKT1
Fc gamma R-mediated phagocytosisWASL;PRKCE;PLA2G4F;LIMK2;MYO10;ARPC5L;LAT;CDC42;FCGR2B
LeishmaniasisTGFB1;IFNG;IL4;HLA-DPA1;HLA-DQA2;ELK1;MAPK13;MYD88;H2-AB1
Staphylococcus aureus infectionHLA-DOB;HLA-DPB1;FCGR3A;FCGR4;C1QC;C2;Hc;FCGR3;HLA-DPA1
TuberculosisCLEC4M;IL12A;LBP;PPP3CA;RAB5C;IFNA2;CD209B;CALML3;IL12B
Systemic lupus erythematosusH3F3A;HLA-DPA1;ACTN4;HIST3H2A;GM14477;HIST2H2BB;CD86;C2;HIST1H3G

FCGR2A has several biochemical functions, for example, IgG binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR2A itself. We selected most functions FCGR2A had, and list some proteins which have the same functions with FCGR2A. You can find most of the proteins on our site.

Function Related Protein
IgG bindingPIP;UMOD;FCGR2B;FCGR1B;FCGR1;FCGR2A;cgr2b;FCGR3A;FCGR2C
protein bindingPPP2R2A;HSCB;VHLL;CIT;LTF;GHRHR;GCG;Icosl;DNAJC15

FCGR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR2A.

UBQLN1; UBQLN1; drozitumab; CRP; SYK

Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
Amirkhosravi, A; Boulaftali, Y; et al. CalDAG-GEFI deficiency protects mice from Fc gamma RIIa-mediated thrombotic thrombocytopenia induced by CD40L and beta 2GPI immune complexes. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 12:2113-2119(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does FCGR2A impact the risk and severity of certain allergic reactions? 03/22/2023

FCGR2A may influence the risk and severity of allergic reactions by modulating the immune response to allergens and antibodies involved in allergic processes.

In the context of infectious diseases, how does FCGR2A contribute to host defense mechanisms? 11/02/2022

FCGR2A participates in host defense against infectious diseases by facilitating the recognition and clearance of pathogens through antibody-mediated immune responses.

How does FCGR2A contribute to the understanding of immunogenetics? 05/26/2021

FCGR2A contributes to the understanding of immunogenetics by highlighting the genetic factors that influence immune responses and the development of immune-related diseases.

How can genetic variations in FCGR2A impact an individual's response to immunotherapy? 03/10/2020

Genetic variations in FCGR2A can influence an individual's response to immunotherapy by affecting the affinity of FCGR2A for antibodies, thereby modulating immune cell activation.

In what ways can FCGR2A be targeted for therapeutic interventions? 12/11/2017

FCGR2A can be targeted for therapeutic interventions through the development of drugs that modulate its activity, offering potential strategies for treating immune-related disorders.

Customer Reviews (3)

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Reviews
03/22/2023

    With its purity and reliability, this protein is poised to contribute significantly to the success of my research objectives by providing accurate and reproducible results.

    02/26/2023

      Its versatility allows for exploration of its extensive involvement in various biochemical and biological processes, providing valuable insights into its role and implications.

      07/24/2017

        The FCGR2A Protein demonstrates remarkable stability and functional efficiency, making it an indispensable tool for diverse scientific applications.

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