FCGR2A
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Official Full Name
Fc fragment of IgG, low affinity IIa, receptor (CD32)
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Overview
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. -
Synonyms
FCGR2A; Fc fragment of IgG, low affinity IIa, receptor (CD32); CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1;
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- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
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- Wheat Germ
- Fc
- Flag
- GST
- His
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- Non
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- Interacting Protein
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Fig1. FCGR2A-related protein interaction network. (Yongmei Dai, 2021)
What is FCGR2A protein?
FCGR2A (Fc gamma receptor IIa) gene is a protein coding gene which situated on the long arm of chromosome 1 at locus 1q23. This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The FCGR2A protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. FCGR2A is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. This protein is consisted of 317 amino acids and is approximately 35 kDa.
What is the Function of FCGR2A protein?
Associated with an ITAM (immunoreceptor tyrosine-based activation motif)- bearing adapter subunit, FCGR2A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. It can also bind to IgG antibodies to promote the phagocytosis and destruction of immune cells (such as monocytes, macrophages, and dendritic cells) against pathogens or foreign bodies labeled by antibodies, thereby enhancing antibody-mediated cytotoxicity.
FCGR2A Related Signaling Pathway
When FCGR2A binds to the Fc part of IgG antibody, it activates the downstream signaling pathway through the ITAM region in its cytoplasm. These signaling pathways, including Syk tyrosine kinase, PI3K/Akt, NF-κB, etc., regulate the activation, proliferation, and inflammatory response of macrophages, dendritic cells, and B cells.
FCGR2A Related Diseases
FCGR2A gene mutation may lead to the occurrence of autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus and so on. It may also lead to the occurrence of allergic diseases, such as asthma and allergic rhinitis. Other research reports FCGR2A functional genetic variant is associated with susceptibility to severe malarial anaemia in Ghanaian children.
Bioapplications of FCGR2A
The anti-ige antibody drug Omalizumab inhibits the FCGR2A signaling pathway by binding to IgE antibodies, thereby reducing allergic reactions. At the same time, some studies are exploring the use of gene editing technology to change the expression level of FCGR2A in order to achieve better immunomodulatory effects.
High Purity
Fig1. SDS-PAGE (FCGR2A-352H) (PROTOCOL for western blot)
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Fig2. Activity Data. (FCGR2A-333H)
Case Study 1: Wei Liao, 2023
Fig1. Immunofluorescence staining detected expression of key genes in PC12 and H9c2 cells and hypoxia-reoxygenated cell models (bar = 50 μm).
Case Study 2: Xin Zhao, 2021
Fig2. The expression of EREG, FCGR2A, CCL4L2, and CTSC increases from the normal pancreas to PASC.
FCGR2A involved in several pathways and played different roles in them. We selected most pathways FCGR2A participated on our site, such as Phagosome, Osteoclast differentiation, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Phagosome | FCGR3A;FCAR;TUBB6;FCGR3B;MBL2;HLA-DOB;BMA1;C1RA;CALRL2 |
Osteoclast differentiation | NCF4;BLNK;PIK3R2;MAPK13;FHL2;RELB;ACP5;PPP3CA;PIK3R3 |
Platelet activation | MAPK12;PLA2G4F;VAMP8;Adcy4;PLCG2;GP5;GNAS;PPP1R12A;GNAI1 |
Fc gamma R-mediated phagocytosis | VASP;WASL;PLCG1;PRKCE;MARCKS;PPAP2C;PPAP2A;AKT2;CDC42 |
Leishmaniasis | NOS2;MAP3K7;ITGA4;IL12B;NFKB1;ITGB2L;TGFB2;FCGR3B;FCGR2A |
Staphylococcus aureus infection | HLA-DQA2;Hc;FCGR1;SELP;FCGR3A;C1RA;HLA-DRB1;HLA-DRB5;CFH |
Tuberculosis | IFNA17;IFNA8;ATP6V0D1;FCGR3;PPP3CA;ATP6V0A2;RAB7A;LBP;Pla2r1 |
Systemic lupus erythematosus | HLA-DOA;HIST1H2AL;HIST3H2BB-PS;HIST1H2BD;FCGR3B;GM6026;FCGR3;HIST1H4L;GM14477 |
FCGR2A has several biochemical functions, for example, IgG binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR2A itself. We selected most functions FCGR2A had, and list some proteins which have the same functions with FCGR2A. You can find most of the proteins on our site.
Function | Related Protein |
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IgG binding | FCER1G;cgr2b;PIP;FCGR2B;FCGR1;FCGRT;FCGR3A;FCGR1B;FCGR2A |
protein binding | ARL2BP;RPS27A;RBPMS;FAM104A;CCBE1;C10orf81;FAM110A;ZNF426;GATAD2A |
FCGR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR2A.
UBQLN1; UBQLN1; drozitumab; CRP; SYK
Research Area
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Customer Reviews (3)
Write a reviewWith its purity and reliability, this protein is poised to contribute significantly to the success of my research objectives by providing accurate and reproducible results.
Its versatility allows for exploration of its extensive involvement in various biochemical and biological processes, providing valuable insights into its role and implications.
The FCGR2A Protein demonstrates remarkable stability and functional efficiency, making it an indispensable tool for diverse scientific applications.
Q&As (5)
Ask a questionFCGR2A may influence the risk and severity of allergic reactions by modulating the immune response to allergens and antibodies involved in allergic processes.
FCGR2A participates in host defense against infectious diseases by facilitating the recognition and clearance of pathogens through antibody-mediated immune responses.
FCGR2A contributes to the understanding of immunogenetics by highlighting the genetic factors that influence immune responses and the development of immune-related diseases.
Genetic variations in FCGR2A can influence an individual's response to immunotherapy by affecting the affinity of FCGR2A for antibodies, thereby modulating immune cell activation.
FCGR2A can be targeted for therapeutic interventions through the development of drugs that modulate its activity, offering potential strategies for treating immune-related disorders.
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