Recombinant Human SFRP1

• Cat.No.: SFRP1-8311H
• Product Overview: Recombinant Human SFRP1 was expressed in HeLa Cells.

Specification

• Description: Secreted Frizzled Related Protein-1 also known as SFRP1 is a member of the secreted frizzled-related proteins (sFRPs) which are glycoproteins that are negative regulators of the Wnt pathway. SFRP1 is strongly expressed throughout embryonic development in different vertebrate species.?It regulates cell proliferation, differentiation and apoptosis and negatively regulates bone formation.?SFRP1 expression might be useful as a novel prognostic marker in early stage breast cancer.?SFRP 1 is also a candidate tumor suppressor gene for lung cancer.
• Source: HeLa Cells
• Species: Human
• Molecular Mass: The molecular weight of Recombinant Human sFRP-1 is Mr 35-40 kDa.
• Endotoxin: <0.1 eu/μg as determined by the lal>
• Purity: >97% by SDS-PAGE and HPLC
• Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: SFRP1 secreted frizzled-related protein 1 [ Homo sapiens ]
• Official Symbol: SFRP1
• Synonyms: SFRP1; secreted frizzled-related protein 1; FRP; FRP 1; SARP2; SARP-2; sFRP-1; secreted apoptosis-related protein 2; FRP1; FrzA; FRP-1
• Gene ID: 6422
• mRNA Refseq: NM_003012
• Protein Refseq: NP_003003
• MIM: 604156
• UniProt ID: Q8N474
• Chromosome Location: 8p11.21
• Pathway: Validated targets of C-MYC transcriptional repression, organism-specific biosystem; Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem; Wnt signaling pathway, conserved biosystem
• Function: PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; cysteine-type endopeptidase activity; drug binding; frizzled binding; heparin binding; identical protein binding