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Official Full Name secreted frizzled-related protein 4
Background Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
Synonyms SFRP4; secreted frizzled-related protein 4; FRP-4; FRPHE; sFRP-4; frizzled protein, human endometrium
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SFRP4-247H Recombinant Human SFRP4 Protein, His-tagged CHO His
    Human SFRP4-2618H Recombinant Human SFRP4, His-tagged E.coli His
    Human SFRP4-2850HCL Recombinant Human SFRP4 cell lysate Human Cell N/A
    Human SFRP4-30079TH Recombinant Human SFRP4 Wheat Germ N/A
    Human SFRP4-359H Recombinant Human SFRP4 Protein, His-tagged E.coli His
    Human SFRP4-864H Recombinant Human SFRP4, His tagged Human Cell His
    Mouse SFRP4-2849MCL Recombinant Mouse SFRP4 cell lysate Human Cell N/A
    Mouse Sfrp4-863M Recombinant Mouse Sfrp4, His tagged Human Cell His
    Rat Sfrp4-362R Recombinant Rat Sfrp4 Protein, His-tagged E.coli His
    Rat SFRP4-5354R Recombinant Rat SFRP4 Protein Mammalian Cell His
    Rhesus Macaque SFRP4-4174R Recombinant Rhesus monkey SFRP4 Protein, His-tagged Mammalian Cell His

    Sfrp4 involved in several pathways and played different roles in them. We selected most pathways Sfrp4 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Sfrp4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway TBL1Y; CAMK2B; SMAD4; SFRP5; CAMK2D2; CUL1A; WNT4; RHOAA; DVL1B; WNT5B

    Sfrp4 has several biochemical functions, for example, NOT G-protein coupled receptor activity, NOT Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Sfrp4 itself. We selected most functions Sfrp4 had, and list some proteins which have the same functions with Sfrp4. You can find most of the proteins on our site.

    Function Related Protein
    NOT G-protein coupled receptor activity SFRP4; SFRP1; SZL; LGR4; LGR6; SFRP1A; SFRP1B; LGR5; FRZB; SFRP2
    NOT Wnt-activated receptor activity SFRP4; SMO; FRZB; SFRP1; SETD6; TSPAN12; SFRP1B; SFRP1A; SZL; SFRP2
    Wnt-protein binding APCDD1; WLS; SFRP1B; SFRP1; SMO; FZD1; SZL; PTPRO; FZD2; Fzd4
    protein binding SHROOM2; CD74; HLCS; FYCO1; GATA4; PEX14; MGARP; LAMTOR1; TRIM42; CDK5R1

    Sfrp4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Sfrp4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Sfrp4.

    AURKA; BUB1; NRAS; ERBB2; PFKM; CKMT1B; MCC; p27958-pro_0000037576; CTNNA1; BMPR1A; PIK3CA; PMS2; PTPN12; PTPRJ; SMAD4; PDGFRL; ychF; CDKN2A; AP2M1; DLC1

    Miao, CG; Huang, C; et al. MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats. CELLULAR SIGNALLING 25:598-608(2013).
    Liu, YA; Kodithuwakku, SP; et al. Excessive ovarian stimulation up-regulates the Wnt-signaling molecule DKK1 in human endometrium and may affect implantation: an in vitro co-culture study. HUMAN REPRODUCTION 25:479-490(2010).

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