SFRP1

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SFRP1

Official Full Name secreted frizzled-related protein 1
Background This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Synonyms SFRP1; secreted frizzled-related protein 1; FRP; FRP1; FrzA; FRP-1; SARP2; SARP-2; sFRP-1; secreted apoptosis-related protein 2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HeLa
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Fc
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SFRP1-221H Recombinant Human SFRP1, His-tagged Mammalian cells His
    Human SFRP1-222H Recombinant Human SFRP1 Mammalian cells N/A
    Human SFRP1-2704H Recombinant Human Secreted Frizzled-related Protein 1 HeLa N/A
    Human SFRP1-2853HCL Recombinant Human SFRP1 cell lysate Human Cell N/A
    Human SFRP1-364H Recombinant Human SFRP1 Protein, His-tagged E.coli His
    Human SFRP1-672H Recombinant Human SFRP1, Fc-tagged, Biotinylated Human Cell Fc
    Human SFRP1-673H Recombinant Human SFRP1, Fc-tagged Human Cell Fc
    Human SFRP1-8311H Recombinant Human SFRP1 HeLa N/A
    Human SFRP1-859H Recombinant Human SFRP1, His tagged Human Cell His
    Mouse SFRP1-2852MCL Recombinant Mouse SFRP1 cell lysate Human Cell N/A
    Mouse Sfrp1-365M Recombinant Mouse Sfrp1 Protein, His-tagged E.coli His
    Mouse SFRP1-790M Recombinant Mouse SFRP1 Protein (Met1-Lys314), His-tagged CHO His
    Mouse Sfrp1-860M Recombinant Mouse Sfrp1, His tagged Human Cell His
    Rat Sfrp1-366R Recombinant Rat Sfrp1 Protein, His-tagged E.coli His
    Rat Sfrp1-861R Recombinant Rat Sfrp1, Fc tagged Human Cell Fc
    Rhesus Macaque SFRP1-4173R Recombinant Rhesus monkey SFRP1 Protein, His-tagged Mammalian Cell His
    Chicken SFRP1-6122C Recombinant Chicken SFRP1 Mammalian Cell His

    SFRP1 involved in several pathways and played different roles in them. We selected most pathways SFRP1 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SFRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway WNT9B; APC; CCND1; CTNNBIP1; PPP3R2; FZD3A; TCF7L1A; WNT5A; NKD1; GSK3B

    SFRP1 has several biochemical functions, for example, NOT G-protein coupled receptor activity, NOT Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SFRP1 itself. We selected most functions SFRP1 had, and list some proteins which have the same functions with SFRP1. You can find most of the proteins on our site.

    Function Related Protein
    NOT G-protein coupled receptor activity SFRP1A; LGR5; SFRP2; SFRP4; LGR6; SZL; FRZB; SFRP1; SFRP1B; LGR4
    NOT Wnt-activated receptor activity SFRP1A; FRZB; SFRP4; SFRP1B; SETD6; SMO; SZL; SFRP2; TSPAN12; SFRP1
    Wnt-protein binding FZD9B; APCDD1; GM12824; ROR2; SZL; FZD3B; CTHRC1; LRP6; FZD8A; FZD7A
    cysteine-type endopeptidase activity USP42; USP50; USP3; CTSK; CASP6; USP2; ATG4D; USP51; USP44; USP5
    drug binding HTR2B; Alb; SRP54B; GRIK1; FNTB; GABRA1; CYP2D6; DHODH; FOLR2; SRP54A
    frizzled binding WNT2B; ROR2; WNT9B; FZD7; NDP; WNT11; FZD1; DVL1B; WNT8B; SDCBP
    heparin binding HSD17B12; SLIT2; C6orf25; ABI3BP; ANG; SAA1; MPO; ZNF207; ITGAM; CFH
    identical protein binding DVL2; MTSS1; CCL3; HAND1; ADORA2A; USP4; SERPINA1D; MUL1A; CHEK2; THBS1
    protein binding SNX8; TRIM59; GABPA; COL23A1; HMGA1; NCK2; STK24; CSN3; TCF12; ZNF302

    SFRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SFRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SFRP1.

    FZD6; WNT2; KIAA1522

    Ghoshal, A; Ghosh, SS; et al. Expression, Purification, and Therapeutic Implications of Recombinant sFRP1. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 175:2087-2103(2015).
    Whyte, MP; Madson, KL; et al. Rapid Skeletal Turnover in a Radiographic Mimic of Osteopetrosis. JOURNAL OF BONE AND MINERAL RESEARCH 29:2601-2609(2014).

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