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Recombinant Human Tyrosinase, GST-tagged

Cat.No. : TYR-220H
Product Overview : Recombinant Human TYR (1 a.a. - 377 a.a.) fused with GST-tag at N-terminal, was expressed in wheat germ.
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Cat. No. : TYR-220H
Description : The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3'' half of this gene.
Source : wheat germ
Molecular Mass : 67.21 kDa
Sequence : MLLAVLYCLLWSFQTSAGHFPRACV SSKNLMEKECCPPWSGDRSPCGQLS GRGSCQNILLSNAPLGPQFPFTGVD DRESWPSVFYNRTCQCSGNFMGFNC GNCKFGFWGPNCTERRLLVRRNIFD LSAPEKDKFFAYLTLAKHTISSDYV IPIGTYGQMKNGSTPMFNDINIYDL FVWMHYYVSMDALLGGSEIWRDIDF AHEAPAFLPWHRLFLLRWEQEIQKL TGDENFTIPYWDWRDAEKCDICTDE YMGGQHPTNPNLLSPASFFSSWQIV CSRLEEYNSHQPLCNGTPEGPLRRN PGNHDKSRTPRLPSSADVEFCLSLT QYESGSMDKAANFSFRNTLEEMGFL HVGWAGLKLLTSRDPPPWPPKMLGL QA
Storagebuffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
Applications : ELISA; WB
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
OfficialSymbol : TYR
Gene Name : TYR tyrosinase [ Homo sapiens (human) ]
Synonyms : TYR; tyrosinase; CMM8; OCA1A; OCAIA; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; oculocutaneous albinism IA; tumor rejection antigen AB
Gene ID : 7299
mRNA Refseq : NM_000372
Protein Refseq : NP_000363
MIM : 606933
UniProt ID : P14679
Chromosome Location : 11q14-q21
Pathway : (S)-reticuline biosynthesis II; L-dopachrome biosynthesis; Melanogenesis; Tyrosine metabolism
Function : copper ion binding; metal ion binding; monooxygenase activity; protein binding; protein heterodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Can low levels of TYR protein be increased with medications? 10/05/2022

There are no drugs that directly increase TYR protein levels, but there are drugs that can treat diseases that cause low TYR protein levels.

Does TYR protein play a role in skin aging? 12/16/2021

This protein may play a role in skin aging because it is involved in the production and metabolism of melanin. However, skin aging is also related to other factors, such as genetics, environment, etc.

What is the relationship between TYR protein and whitening products? 06/21/2021

Some whitening products claim to inhibit the TYR protein, thereby reducing the production of melanin. However, the efficacy and safety of these products have yet to be proven.

How to increase the level of TYR protein through diet? 12/29/2020

It is difficult to directly increase the level of TYR protein through diet because TYR protein is mainly genetically determined. However, the presence of copper in the diet can promote the function of the TYR protein.

What does TYR protein have to do with tanning? 12/27/2020

TYR is not directly related to tanning. Tanning is a process by which skin cells produce melanin due to ultraviolet rays.

What is the relationship between TYR protein and skin cancer? 04/20/2020

TYR protein may be involved in the occurrence and progression of skin cancer because it is involved in the production and metabolism of melanin.

Customer Reviews (3)

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Reviews
04/09/2022

    Repeatability is good, the results of multiple experiments are highly consistent, and the repeatability is particularly good.

    03/31/2021

      High solubility, can be dissolved in various types of reagents, easy to operate.

      01/09/2021

        Not easy to inactivate, tried a variety of experimental conditions, still active.

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