Recombinant Human Tyrosinase, GST-tagged
Cat.No. : | TYR-220H |
Product Overview : | Recombinant Human TYR (1 a.a. - 377 a.a.) fused with GST-tag at N-terminal, was expressed in wheat germ. |
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- Gene Information
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Cat. No. : | TYR-220H |
Description : | The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3'' half of this gene. |
Source : | wheat germ |
Molecular Mass : | 67.21 kDa |
Sequence : | MLLAVLYCLLWSFQTSAGHFPRACV SSKNLMEKECCPPWSGDRSPCGQLS GRGSCQNILLSNAPLGPQFPFTGVD DRESWPSVFYNRTCQCSGNFMGFNC GNCKFGFWGPNCTERRLLVRRNIFD LSAPEKDKFFAYLTLAKHTISSDYV IPIGTYGQMKNGSTPMFNDINIYDL FVWMHYYVSMDALLGGSEIWRDIDF AHEAPAFLPWHRLFLLRWEQEIQKL TGDENFTIPYWDWRDAEKCDICTDE YMGGQHPTNPNLLSPASFFSSWQIV CSRLEEYNSHQPLCNGTPEGPLRRN PGNHDKSRTPRLPSSADVEFCLSLT QYESGSMDKAANFSFRNTLEEMGFL HVGWAGLKLLTSRDPPPWPPKMLGL QA |
Storagebuffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer. |
Applications : | ELISA; WB |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
OfficialSymbol : | TYR |
Gene Name : | TYR tyrosinase [ Homo sapiens (human) ] |
Synonyms : | TYR; tyrosinase; CMM8; OCA1A; OCAIA; SHEP3; LB24-AB; SK29-AB; monophenol monooxygenase; oculocutaneous albinism IA; tumor rejection antigen AB |
Gene ID : | 7299 |
mRNA Refseq : | NM_000372 |
Protein Refseq : | NP_000363 |
MIM : | 606933 |
UniProt ID : | P14679 |
Chromosome Location : | 11q14-q21 |
Pathway : | (S)-reticuline biosynthesis II; L-dopachrome biosynthesis; Melanogenesis; Tyrosine metabolism |
Function : | copper ion binding; metal ion binding; monooxygenase activity; protein binding; protein heterodimerization activity |
Products Types
◆ Recombinant Protein | ||
TYR-2965H | Recombinant Human TYR Protein, MYC/DDK-tagged | +Inquiry |
TYR-238H | Recombinant Human TYR Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Tyr-6757M | Recombinant Mouse Tyr Protein, Myc/DDK-tagged | +Inquiry |
TYR-2286H | Recombinant Human TYR Protein, His (Fc)-Avi-tagged | +Inquiry |
TYR-1551H | Recombinant Human TYR Protein (19-377 aa), His-tagged | +Inquiry |
◆ Lysates | ||
TYR-1869HCL | Recombinant Human TYR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0836 | Tyrosine Colorimetric Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (6)
Ask a questionThere are no drugs that directly increase TYR protein levels, but there are drugs that can treat diseases that cause low TYR protein levels.
This protein may play a role in skin aging because it is involved in the production and metabolism of melanin. However, skin aging is also related to other factors, such as genetics, environment, etc.
Some whitening products claim to inhibit the TYR protein, thereby reducing the production of melanin. However, the efficacy and safety of these products have yet to be proven.
It is difficult to directly increase the level of TYR protein through diet because TYR protein is mainly genetically determined. However, the presence of copper in the diet can promote the function of the TYR protein.
TYR is not directly related to tanning. Tanning is a process by which skin cells produce melanin due to ultraviolet rays.
TYR protein may be involved in the occurrence and progression of skin cancer because it is involved in the production and metabolism of melanin.
Customer Reviews (3)
Write a reviewRepeatability is good, the results of multiple experiments are highly consistent, and the repeatability is particularly good.
High solubility, can be dissolved in various types of reagents, easy to operate.
Not easy to inactivate, tried a variety of experimental conditions, still active.
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