"IYD" Related Products

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Recombinant Human IYD, His-tagged

Cat.No.: IYD-5096H
Product Overview: Recombinant human IYD protein, fused to His-tag at N-terminus, was expressed in E.coli.
Description: IYD is an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
Molecular Mass: 25.1kDa (214aa)
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSDRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNE
Purity: >90% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml (determined by Bradford assay)
Gene Name: IYD iodotyrosine deiodinase [ Homo sapiens (human) ]
Official Symbol: IYD
Synonyms: IYD;TDH4; DEHAL1; C6orf71; dJ422F24.1;iodotyrosine dehalogenase 1;IYD-1
Gene ID: 389434
mRNA Refseq: NM_001164694.1
Protein Refseq: NP_001158166.1
MIM: 612025
UniProt ID: Q6PHW0
Chromosome Location: 6q25.1
Pathway: Amine-derived hormones;Metabolism;Metabolism of amino acids and derivatives;Thyroid hormone synthesis;Thyroid hormone synthesis;Thyroxine biosynthesis
Function: oxidoreductase activity

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