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Recombinant Human TARDBP, MYC/DDK-tagged

Cat.No.: TARDBP-35H
Product Overview: Recombinant Human TARDBP, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Source: HEK293 cells
Species: Human
Tag: MYC/DDK
Molecular Mass: 44.6 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: TARDBP TAR DNA binding protein [ Homo sapiens (human) ]
Official Symbol: TARDBP
Synonyms: TARDBP; TDP-43; TAR DNA binding protein; ASL 10; TAR DNA-binding protein 43; TDP43; TAR DNA-binding protein 43; OTTHUMP00000002173; TRA DNA-binding protein-43
Gene ID: 23435
mRNA Refseq: NM_007375
Protein Refseq: NP_031401
MIM: 605078
UniProt ID: Q13148
Chromosome Location: 1p36.22
Function: RNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; double-stranded DNA binding

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