Recombinant Human TARDBP Protein

• Cat.No.: TARDBP-22H
• Product Overview: Recombinant human TARDBP protein (1-414aa) without tag was expressed in E.coli.

Specification

• Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
• Source: E. coli
• Species: Human
• Form: Liquid
• Molecular Mass: 44.7 kDa
• Purity: > 85% by SDS-PAGE
• Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/mL (determined by Bradford assay)
• Storage Buffer: In 20mM Tris-HCl(pH8.0) containing 0.1M NaCl, 1mM DTT, 1mM EDTA, 10% glycerol

Gene Information

• Gene Name: TARDBP TAR DNA binding protein [ Homo sapiens (human) ]
• Official Symbol: TARDBP
• Synonyms: TARDBP; TAR DNA binding protein; ALS10; TDP-43; TAR DNA-binding protein 43; TAR DNA-binding protein-43
• Gene ID: 23435
• mRNA Refseq: NM_007375
• Protein Refseq: NP_031401
• MIM: 605078
• UniProt ID: Q13148