Recombinant Human CDX2

• Cat.No.: CDX2-27917TH
• Product Overview: Recombinant full length Human CDX2 with N terminal proprietary tag, 60.54kDa.

Specification

• Description: The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription (German et al.
• Protein length: 313 amino acids
• Molecular Weight: 60.540kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDY GGYHVAAAAAAAANLDSAQSPGPSWPAAYGAPLREDWNGY APGGAAAAANAVAHGPNGGSPAAAMGYSSPADYHPHHHPH HHPHHPAAAPSCASGLLQTLNPGPPGPAATAAAEQLSPGG QRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLE LEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAK ERKINKKKLQQQQQQQPPQPPPPPPQPPQPQPGPLRSVPE PLSPVSSLQASVSGSVPGVLGPTGGVLNPTVTQ
• Sequence Similarities: Belongs to the Caudal homeobox family.Contains 1 homeobox DNA-binding domain.

Gene Information

• Gene Name: CDX2 caudal type homeobox 2 [ Homo sapiens ]
• Official Symbol: CDX2
• Synonyms: CDX2; caudal type homeobox 2; caudal type homeo box transcription factor 2 , CDX3; homeobox protein CDX-2
• Gene ID: 1045
• mRNA Refseq: NM_001265
• Protein Refseq: NP_001256
• MIM: 600297
• Uniprot ID: Q99626
• Chromosome Location: 13q12.2
• Pathway: Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Regulation of Insulin Secretion, organism-specific biosystem; Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem
• Function: sequence-specific DNA binding transcription factor activity; transcription corepressor activity; transcription regulatory region sequence-specific DNA binding