CDX2

Official Full Name

caudal type homeobox 2
Overview

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major;regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in;early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal;inflammation and tumorigenesis.
Synonyms

CDX2; caudal type homeobox 2; caudal type homeo box transcription factor 2 , CDX3; homeobox protein CDX-2; caudal-type homeobox protein 2; caudal type homeobox transcription factor 2; caudal type homeo box transcription factor 2; CDX3; CDX-3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CDX2-1083H	Recombinant Human CDX2 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CDX2-27917TH	Recombinant Human CDX2	Wheat Germ	Non	313 amino acids	Inquiry
Human	CDX2-11075H	Recombinant Human CDX2, His-tagged	E.coli	His	1-180a.a.	$319 / 25μg
Human	CDX2-7602HCL	Recombinant Human CDX2 293 Cell Lysate	HEK293	Non		Inquiry
Human	CDX2-1186H	Recombinant Human CDX2 Protein (Met1-Gln313), N-GST tagged	E.coli	GST	Met1-Gln313	Inquiry
Human	CDX2-600H	Recombinant Human CDX2 Protein, His/GST-tagged	E.coli	His&GST	Met1~Gln313	Inquiry
Human	CDX2-75HF	Recombinant Full Length Human CDX2 Protein	In Vitro Cell Free System		313 amino acids	Inquiry
Human	CDX2-1835H	Recombinant Human CDX2 protein, GST-tagged	E.coli	GST	1-180 aa	$319 / 25μg
Human	CDX2-3265HF	Recombinant Full Length Human CDX2 Protein, GST-tagged	In Vitro Cell Free System	GST	313 amino acids	Inquiry
Mouse	CDX2-3242M	Recombinant Mouse CDX2 Protein	Mammalian Cell	His		Inquiry
Mouse	CDX2-1552M	Recombinant Mouse CDX2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	CDX2-1552M-B	Recombinant Mouse CDX2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	CDX2-5884C	Recombinant Chicken CDX2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

CDX2 involved in several pathways and played different roles in them. We selected most pathways CDX2 participated on our site, such as Incretin synthesis, secretion, and inactivation, Metabolism of proteins, Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Incretin synthesis, secretion, and inactivation	SPCS3;DPP4;SLC38A8;CDX2;O3far1;PCSK1;GRP;GPR120;GPR119
Metabolism of proteins	CXXC1;SENP1;SEC63;TIMM50;SFTPB;NEU3;DOHH;ST6GAL2B;SLC30A5
Peptide hormone metabolism	CDX2;ACE;SLC30A6;EXOC8;DPP4;CGB5;CPA3;SPCS3;SLC38A8

CDX2 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, transcription corepressor activity, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDX2 itself. We selected most functions CDX2 had, and list some proteins which have the same functions with CDX2. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II distal enhancer sequence-specific DNA binding	SIX3;MEOX2;SOX10;NFE2L2;MIXL1;TAL1;T;MSC;NR1H4
transcription corepressor activity	MXD1;HDAC4;SFMBT1;CTCF;SKI;SAP30;JUB;ASXL1;NCOR1
transcription factor activity, sequence-specific DNA binding	RERE;SMAD3A;PLAGL2;TAF5L;MYCLB;VAV1;FLI1;ETV6;UBP1
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	E2F7;POU5F1;MITF;KLF6A;DMBX1;CGGBP1;NFKB1;FOXD3;PURB

CDX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDX2.

MEP1A; cdx2_human_gene

Research Area

Epithelial Stem Cell Transcription Factors

Apical-basal Polarity Effectors

Embryonic and Induced Pluripotent Stem Cell Markers

Cancer Stem Cell Transcription Factors

Trophoblast Stem Cell Markers

Agaimy, A; Lell, M; et al. 'Neuroendocrine' middle ear adenomas: consistent expression of the transcription factor ISL1 further supports their neuroendocrine derivation. HISTOPATHOLOGY 66:182-191(2015).

Jeon, JH; Suh, HN; et al. Glucosamine-Induced OGT Activation Mediates Glucose Production Through Cleaved Notch1 and FoxO1, Which Coordinately Contributed to the Regulation of Maintenance of Self-Renewal in Mouse Embryonic Stem Cells. STEM CELLS AND DEVELOPMENT 23:2067-2079(2014).