Recombinant Human DLL4

• Cat.No.: DLL4-26674TH
• Product Overview: Recombinant fragment, corresponding to amino acids 27-524 of Human DLL4 expressed in 293 cells; 498 amino acids, 54.0 kDa.

Specification

• Description: This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
• Tissue specificity: Expressed in vascular endothelium.
• Biological activity: Biological Activity :DLL4-26674TH, when immobilized at concentrations >1.5 μg/mL will inhibit myogenesis in C2C12 cells.
• Form: Lyophilised:Reconstituted DLL4-26674TH is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
• Purity: >95% by SDS-PAGE
• Storage: Store at -20°C. Stable for 12 months at -20°C
• Sequences of amino acids: SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NGCRHGTCST PWQCTCDEGW GGLFCDQDLN YCTHHSPCKN GATCSNSGQR SYTCTCRPGY TGVDCELELS ECDSNPCRNG GSCKDQEDGY HCLCPPGYYG LHCEHSTLSC ADSPCFNGGS CRERNQGANY ACECPPNFTG SNCEKKVDRC TSNPCANGGQ CLNRGPSRMC RCRPGFTGTY CELHVSDCAR NPCAHGGTCH DLENGLMCTC PAGFSGRRCE VRTSIDACAS SPCFNRATCY TDLSTDTFVC NCPYGFVGSR CEFPVGLP
• Sequence Similarities: Contains 1 DSL domain.Contains 8 EGF-like domains.

Gene Information

• Gene Name: DLL4 delta-like 4 (Drosophila) [ Homo sapiens ]
• Official Symbol: DLL4
• Synonyms: DLL4; delta-like 4 (Drosophila); delta like 4 homolog (Drosophila); delta-like protein 4
• Gene ID: 54567
• mRNA Refseq: NM_019074
• Protein Refseq: NP_061947
• MIM: 605185
• Uniprot ID: Q9NR61
• Chromosome Location: 15q14
• Pathway: Delta-Notch Signaling Pathway, organism-specific biosystem; Notch receptor binds with a ligand, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem
• Function: Notch binding; calcium ion binding