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DLL4

  • Official Full Name

    delta-like 4 (Drosophila)

  • Overview

    This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
  • Synonyms

    DLL4; delta-like 4 (Drosophila); hdelta2; delta-like protein 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2; drosophila Delta homolog 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Human
  • Mouse
  • Rat
  • Rhesus
  • Zebrafish
  • CHO cells
  • E.coli
  • HEK293
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Wheat Germ
  • C
  • His
  • Avi
  • Fc
  • GST
  • hFc
  • His (Fc)
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DLL4-2235H Active Recombinant Human DLL4 protein, His-tagged HEK293 His Met1-Pro524
Human DLL4-686H Active Recombinant Human DLL4 protein, Fc-tagged HEK293 Fc Ser27-Pro524
Human DLL4-051H Active Recombinant Human DLL4 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Ser27-Pro524
Human DLL4-0287H Active Recombinant Human DLL4 protein, hFc-tagged HEK293 hFc Met1-Pro524
Human DLL4-2687H Recombinant Human DLL4 Protein, GST-tagged Wheat Germ GST
Human DLL4-26674TH Recombinant Human DLL4 N/A
Human DLL4-26672TH Recombinant Human DLL4, Fc-tagged HEK293 Fc 529 amino acids
Human DLL4-934H Recombinant Human Delta-like 4 (Drosophila) HEK293 N/A
Human DLL4-2507HCL Recombinant Human DLL4 cell lysate Human Cell N/A
Human DLL4-2147H Recombinant Human DLL4 Protein (Leu16-Ala539), N-His tagged E.coli N-His Leu16-Ala539
Human DLL4-201H Recombinant Human DLL4 Protein, His-tagged HEK293 His 685
Human DLL4-1349H Recombinant Human DLL4 Protein, His&GST-tagged E.coli N-His&GST Val173-Glu518
Human DLL4-354H Active Recombinant Human DLL4 protein HEK293 N/A Met1-Pro524
Human DLL4-071H Recombinant Human DLL4 Protein, Ser27-Pro524, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Ser27-Pro524
Human DLL4-202H Recombinant Human DLL4 Protein, Fc-tagged HEK293 Fc 685
Human DLL4-001H Recombinant Human DLL4 Protein, His-tagged HEK293 His 27-524aa
Mouse Dll4-2288M Active Recombinant Mouse Dll4 protein, His-tagged HEK293 His Met1-Pro525
Mouse Dll4-451M Active Recombinant Mouse Dll4, His-tagged Mammalian cells His
Mouse Dll4-70M Recombinant Mouse Dll4 protein, His-tagged Insect Cell His
Mouse DLL4-2495MCL Recombinant Mouse DLL4 cell lysate Human Cell N/A
Mouse Dll4-2402M-B Recombinant Mouse Dll4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Dll4-2402M Recombinant Mouse Dll4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CAB11525RM Rabbit Anti-Mouse Delta-Like 4 Monoclonal Antibody Rabbit N/A
Rat Dll4-1647R Recombinant Rat Dll4 protein, His-tagged E.coli His Gly215~Ser331 (Accession # D3ZHH1)
Rat Dll4-1648R Recombinant Rat Dll4 protein, His & GST-tagged E.coli His/GST Gly215~Ser331 (Accession # D3ZHH1)
Rhesus DLL4-1021R Active Recombinant Rhesus DLL4 Protein (Met1-Pro528), His-tagged HEK293 His Met1-Pro528
Zebrafish DLL4-4900Z Recombinant Zebrafish DLL4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DLL4 Related Articles
  • DLL4 Related Research Area

DLL4 involved in several pathways and played different roles in them. We selected most pathways DLL4 participated on our site, such as Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Notch signaling pathwayNUMB;JAG1B;MARK2;JAG2B;DTX3;RFNG;APH1B;DTX4;RBPJA

DLL4 has several biochemical functions, for example, Notch binding, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLL4 itself. We selected most functions DLL4 had, and list some proteins which have the same functions with DLL4. You can find most of the proteins on our site.

Function Related Protein
Notch bindingDLL3;NCOR2;GALNT11;EGFL7;DNER;JAG1;ADAM17;AAK1;NOV
calcium ion bindingPCDHB13;GUCA1A;S100A14;GM5077;PCDH2G12;ANXA13;PCDH2AC;EFEMP2B;ASPN
protein bindingGRAP;MED24;RFESD;RGS2;TERF1;CCDC55;STOML1;CNIH2;PLDN

DLL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLL4.

Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
Minuzzo, S; Agnusdei, V; et al. DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice. CARCINOGENESIS 36:115-121(2015).
  • Q&As
  • Reviews

Q&As (5)

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What role does DLL4 play in vascular diseases, such as atherosclerosis? 03/27/2023

DLL4 is implicated in the regulation of vascular inflammation and plaque formation, making it a potential target for atherosclerosis treatments.

How does DLL4 contribute to Alzheimer's disease pathogenesis? 10/27/2022

DLL4 has been linked to Alzheimer's disease as it can influence amyloid-beta accumulation and the activation of microglia in the brain.

Can DLL4 be used as a biomarker for any diseases? 10/01/2021

DLL4 levels can serve as a potential biomarker in some diseases, such as certain cancers, where it may indicate disease progression.

What are the challenges in developing DLL4-targeted therapies? 01/20/2018

Challenges include potential side effects, the need for personalized treatment approaches, and the complexity of the Notch signaling pathway.

How does DLL4 affect tissue regeneration? 05/23/2017

DLL4 can modulate tissue regeneration by influencing stem cell behavior and promoting tissue repair processes.

Customer Reviews (3)

Write a review
Reviews
07/29/2022

    They ensure a consistent and reliable supply of DLL4 protein, minimizing any potential disruptions in my experimental workflow.

    05/01/2021

      the manufacturer's commitment to scientific collaboration and knowledge sharing greatly enhances my research experience.

      12/09/2017

        This collaborative approach empowers me to integrate cutting-edge knowledge, explore innovative techniques, and expand the impact of my research.

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