Recombinant Human FOXA1

• Cat.No.: FOXA1-28105TH
• Product Overview: Recombinant full length Human FOXA1; amino acids 1-472, 472 amino acids, Predicted MWt 49.1 kDa.

Specification

• Description: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
• Protein length: 472 amino acids
• Molecular Weight: 49.100kDa
• Source: E. coli
• Tissue specificity: Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50mM HEPES, 5mM Calcium chloride, 3mM DTT, 500 mM L-arginine, 300 mM guanidine-HCl, 5 mM cystamine, 5 mM cysteamine, pH 7.5
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 fork-head DNA-binding domain.

Gene Information

• Gene Name: FOXA1 forkhead box A1 [ Homo sapiens ]
• Official Symbol: FOXA1
• Synonyms: FOXA1; forkhead box A1; hepatocyte nuclear factor 3, alpha , HNF3A; hepatocyte nuclear factor 3-alpha
• Gene ID: 3169
• mRNA Refseq: NM_004496
• Protein Refseq: NP_004487
• MIM: 602294
• Uniprot ID: P55317
• Chromosome Location: 14q12-q13
• Pathway: Direct p53 effectors, organism-specific biosystem; FOXA transcription factor networks, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem
• Function: DNA bending activity; DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; double-stranded DNA binding; protein domain specific binding