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Official Full Name forkhead box A2
Background This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Synonyms FOXA2; forkhead box A2; HNF3B; TCF3B; hepatocyte nuclear factor 3-beta; HNF-3B; TCF-3B; HNF-3-beta; forkhead box protein A2; transcription factor 3B; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FOXA2-127H Recombinant Human FOXA2 E.coli N/A
    Human FOXA2-28944TH Recombinant Human FOXA2 E.coli N/A
    Human FOXA2-4433H Recombinant Human FOXA2 Protein, GST-tagged Wheat Germ GST
    Human FOXA2-6163HCL Recombinant Human FOXA2 293 Cell Lysate HEK293 N/A
    Mouse FOXA2-5976M Recombinant Mouse FOXA2 Protein Mammalian Cell His
    Rat FOXA2-2383R Recombinant Rat FOXA2 Protein Mammalian Cell His
    Chicken FOXA2-6334C Recombinant Chicken FOXA2 Mammalian Cell His
    Zebrafish FOXA2-8588Z Recombinant Zebrafish FOXA2 Mammalian Cell His

    FOXA2 involved in several pathways and played different roles in them. We selected most pathways FOXA2 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Maturity onset diabetes of the young NKX6-1; PKLR; NKX6; HHEX; HNF1A; NR5A2; IAPP; BHLHA15; FOXA3; ONECUT1

    FOXA2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXA2 itself. We selected most functions FOXA2 had, and list some proteins which have the same functions with FOXA2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding TBX10; THAP11; PRRX1A; TCEB3C; SMARCA5; ZFP354A; APEX2; DMRT2; PML; SAP30L
    RNA polymerase II core promoter proximal region sequence-specific DNA binding FLI1; RUNX2; ATF4; CREB1; RFX8; LEF1; CREB3L2; RBPJB; POU2F2; ELF3
    RNA polymerase II transcription factor activity, sequence-specific DNA binding KLF11; FOXG1C; HIF1AL2; NPAS4; FOXC1A; ETS1; SP3A; OVOL3; FOXJ1A; RUNX2A
    protein domain specific binding ACSL3; NEDD4; FOXA2; CBX3; RHOA; KPNB1; IKBKG; PHRF1; HIST2H4; TWIST2
    transcription factor activity, sequence-specific DNA binding TCF19; PAX8; PRRXL1; TEF; NEUROD2; NFIX; NFATC1; PKNOX1; EVX1; CLOCKB
    transcription factor binding PER1; REST; TRIB1; PITX2; ATG7; ZFPM2; HMGA1-RS1; JUN; STK4; TFDP1
    transcription regulatory region DNA binding TCF7L1B; TBX16; ZFP639; CARM1; BCL11B; FOS; NKX3; ZFP161; GATA6; KLF4

    FOXA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXA2.


    Liang, S; Li, HC; et al. Pulmonary endoderm, second heart field and the morphogenesis of distal outflow tract in mouse embryonic heart. DEVELOPMENT GROWTH & DIFFERENTIATION 56:276-292(2014).
    Reers, S; Pfannerstill, AC; et al. Stem cell profiling in head and neck cancer reveals an Oct-4 expressing subpopulation with properties of chemoresistance. ORAL ONCOLOGY 50:155-162(2014).

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