|Official Full Name||forkhead box A2|
|Background||This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]|
|Synonyms||FOXA2; forkhead box A2; HNF3B; TCF3B; hepatocyte nuclear factor 3-beta; HNF-3B; TCF-3B; HNF-3-beta; forkhead box protein A2; transcription factor 3B; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
FOXA2 involved in several pathways and played different roles in them. We selected most pathways FOXA2 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Maturity onset diabetes of the young||NKX6-1; PKLR; NKX6; HHEX; HNF1A; NR5A2; IAPP; BHLHA15; FOXA3; ONECUT1|
FOXA2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXA2 itself. We selected most functions FOXA2 had, and list some proteins which have the same functions with FOXA2. You can find most of the proteins on our site.
|DNA binding||TBX10; THAP11; PRRX1A; TCEB3C; SMARCA5; ZFP354A; APEX2; DMRT2; PML; SAP30L|
|RNA polymerase II core promoter proximal region sequence-specific DNA binding||FLI1; RUNX2; ATF4; CREB1; RFX8; LEF1; CREB3L2; RBPJB; POU2F2; ELF3|
|RNA polymerase II transcription factor activity, sequence-specific DNA binding||KLF11; FOXG1C; HIF1AL2; NPAS4; FOXC1A; ETS1; SP3A; OVOL3; FOXJ1A; RUNX2A|
|protein domain specific binding||ACSL3; NEDD4; FOXA2; CBX3; RHOA; KPNB1; IKBKG; PHRF1; HIST2H4; TWIST2|
|transcription factor activity, sequence-specific DNA binding||TCF19; PAX8; PRRXL1; TEF; NEUROD2; NFIX; NFATC1; PKNOX1; EVX1; CLOCKB|
|transcription factor binding||PER1; REST; TRIB1; PITX2; ATG7; ZFPM2; HMGA1-RS1; JUN; STK4; TFDP1|
|transcription regulatory region DNA binding||TCF7L1B; TBX16; ZFP639; CARM1; BCL11B; FOS; NKX3; ZFP161; GATA6; KLF4|
FOXA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXA2.