FOXA1
-
Official Full Name
forkhead box A1
-
Overview
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. -
Synonyms
FOXA1; forkhead box A1; hepatocyte nuclear factor 3, alpha , HNF3A; hepatocyte nuclear factor 3-alpha; HNF-3A; TCF-3A; HNF-3-alpha; forkhead box protein A1; transcription factor 3A; hepatocyte nuclear factor 3, alpha; HNF3A; TCF3A; MGC33105;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FOXA1 Related Articles
- FOXA1 Related Research Area
FOXA1 involved in several pathways and played different roles in them. We selected most pathways FOXA1 participated on our site, such as Direct p53 effectors, FOXA transcription factor networks, FOXA1 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Direct p53 effectors | HIC1;CEBPZ;DDB2;GDF15;PCBP4;ZNF385A;NDRG1;ARID3A;DUSP5 |
| FOXA transcription factor networks | |
| FOXA1 transcription factor network | NFIB;NFIC;NFIA;FOXA1;POU2F1;DSCAM;CC10;NR2F2;CYP2C18 |
| FOXA2 and FOXA3 transcription factor networks | UCP2;FOXF1;CPT1B;CEBPA;CPT1A;CPT1C;FOXA1;KCNJ11;TTR |
| Prostate Cancer | MDM2;NFKB1;PIK3CG;PIK3R3;ARID1A;PIK3R1;MAPK3;SMARCA4;NFKBIA |
FOXA1 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXA1 itself. We selected most functions FOXA1 had, and list some proteins which have the same functions with FOXA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | H1M;POLM;POU6F1;ZNF560;ERCC3;ZNF526;ANG3;MBD3A;ZNF143B |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | JUNBA;FOXN2B;SOX8A;HIF1AB;TFAP2A;POU5F1;FOXC1;HOXA13A;RUNX2A |
| protein domain specific binding | TFDP1;CASKIN1;STX1B;CHMP1B;IPCEF1;RAB27A;RAN;AKAP5;HOXB1 |
| sequence-specific DNA binding | NR1H4;HOXC10A;DLX6;TCF7L2;HOXB9A;POU2F1A;TSN;POU4F1;LBX1A |
| transcription factor activity, sequence-specific DNA binding | ENO1;PAX7;ZNF286A;IRF1A;PA2G4A;MAX;MYCN;TCF3;SMAD3A |
| transcription factor binding | NKX2-5;SOX17;NFYC;KCTD1;CD34;HES4;SOST;HMGA1-RS1;ATG7 |
| transcription regulatory region DNA binding | HOXA13;CDK5RAP2;GLIS2;SP1;GATA6;SMAD3;HIVEP2A;ETV5;TAF9 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | EGR2;TP53;GMEB1;MTF1;EBF2;FOXJ1;PBX1;OTX2;ZSCAN21 |
FOXA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXA1.
RARA; AR; SEZ6L2; FOXC1; erbb3_human_gene; myc_human_gene; GREB1; ESR1; TBP; GATA3; FOXA2
- Q&As
- Reviews
Q&As (5)
Ask a questionFOXA1 has been implicated in the development and progression of hepatocellular carcinoma, with its expression levels serving as a potential prognostic marker.
Yes, FOXA1 is a key co-regulator of estrogen receptor (ER) signaling, influencing the expression of ER-responsive genes and impacting the response to anti-estrogen therapies.
FOXA1 expression has been associated with specific subtypes of lung cancer and may hold potential as a predictive biomarker for treatment response.
Yes, there are clinical trials focused on understanding the role of FOXA1 in cancer and exploring its potential as a therapeutic target in various cancer types.
High FOXA1 expression has been linked to resistance to anti-androgen therapy in prostate cancer, highlighting its clinical relevance in treatment decision-making.
Customer Reviews (3)
Write a reviewThe company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.
Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.
In addition to its scientific merits, the manufacturer of FOXA1 protein stands out for its outstanding technical support.
Ask a Question for All FOXA1 Products
Required fields are marked with *
My Review for All FOXA1 Products
Required fields are marked with *
