Recombinant Human PRKACA

• Cat.No.: PRKACA-31113TH
• Product Overview: Full length human recombinant PRKACA, with a MW of 41 kDa.

Specification

• Description: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 5mM EDTA, 5mM Beta mercaptoethanol, 25mM Potassium phosphate, 150mM Sodium chloride, pH 6.5
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: PRKACA protein kinase, cAMP-dependent, catalytic, alpha [ Homo sapiens ]
• Official Symbol: PRKACA
• Synonyms: PRKACA; protein kinase, cAMP-dependent, catalytic, alpha; cAMP-dependent protein kinase catalytic subunit alpha; PKACa
• Gene ID: 5566
• mRNA Refseq: NM_002730
• Protein Refseq: NP_002721
• MIM: 601639
• Uniprot ID: P17612
• Chromosome Location: 19p13.1
• Pathway: Adaptive Immune System, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem
• Function: ATP binding; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase inhibitor activity; nucleotide binding