PRKACA
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Official Full Name
protein kinase, cAMP-dependent, catalytic, alpha
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Overview
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the;cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The;inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the;dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric;catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans.;The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of;cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been;observed. -
Synonyms
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha; cAMP-dependent protein kinase catalytic subunit alpha; PKACa; PKA C-alpha; protein kinase A catalytic subunit; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; MGC48865; MGC102831;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Dog
- Human
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- C
- His
- DDK
- GST
- His (Fc)
- Avi
- Myc
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- PRKACA Related Research Area
PRKACA involved in several pathways and played different roles in them. We selected most pathways PRKACA participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | CD14;CACNA1C;RPS6KA6;MAP2K2;CACNA2D3;CACNG7;TNFRSF1A;PAK2B;CACNA1BA |
| Ras signaling pathway | CSF1;BCL2L1;INS1;RAB5C;GRIN2B;PDGFD;GNB1;PRKACA;FGF14 |
| Calcium signaling pathway | CACNA1SA;ADORA2B;ADORA2A;TACR3L;DRD1;ITPR1;SLC25A5;TNNC1;TRHR |
| cAMP signaling pathway | MAPK8;CALML3;CNGA3;NFATC1;CALM3;GHSR;PAK1;GRIN1;GNAI3 |
| Chemokine signaling pathway | ROCK2;STAT2;IKBKG;SOS1;CXCL11;PPBP;CCR1L1;GNG12;CCL27 |
| Oocyte meiosis | YWHAE1;PRKACBB;PPP3CB;AURKA;CALM;CALM3A;CDK1;CALML5;CALM3 |
| Apoptosis | DSG3;BAX;MYC;CASP7;PIK3R3;NFKBIA;CAPN2L;BIRC8;ENDOG |
| Adrenergic signaling in cardiomyocytes | CACNA1SA;TNNT2A;BCL2A;CAMK2D1;AGTR1A;PLCB3;CACNA2D1A;CACNA1C;SLC9A1 |
| Vascular smooth muscle contraction | PLA2G6;CALD1;ADRA1BB;PLA2G1B;PTGIR;PRKACBA;PRKCE;ROCK1;ARHGEF12 |
| Wnt signaling pathway | FOSL1;MYCB;RAC3A;CCND3;SFRP5;PRKCBB;MAPK8A;TLE3A;FOSL1A |
| Hedgehog signaling pathway | WNT2BA;WNT10B;CSNK1G2A;BMP4;PRKACAB;WNT2B;WNT2BB;GAS1B;WNT8B |
| Gap junction | CSNK1DB;ADCY1B;DRD1A;SOS1;GRM1;TUBA3B;TUBA4L;HRASB;PRKG1 |
| Platelet activation | GUCY1A3;LYN;AKT2;PTGS1;PLA2G4C;PLCB2;PPP1CC;MYLK3;FGB |
| Circadian entrainment | ADCYAP1R1;PER2;GNAO1;GRIA1;CACNA1G;KCNJ5;CAMK2B;RASD1;GNAI2 |
| Long-term potentiation | PRKACG;BRAF;CALML3;PPP3CB;CALM4;CAMK2A;RPS6KA6;ITPR1;RAP1A |
| Retrograde endocannabinoid signaling | GNG11;GABRA5;ITPR3;MAPK9;GNB4;MAPK1;GNAI2;GABRR2;MAPK8 |
| Glutamatergic synapse | GNG5;GRIK1;GRIN2B;PRKACG;GRM4;GNG12;PPP3R2;GRM6;GNG3 |
| Cholinergic synapse | CHRM1;CAMK2A;PRKCB;PIK3R5;CHRM3;MAPK3;CHRM5;PIK3R3;PIK3CA |
| Serotonergic synapse | HTR3A;TPH2;ALOX12B;GNG10;BRAF;TRPC1;HTR4;GNAI1;NRAS |
| GABAergic synapse | SLC38A2;GABRR1;GABRA6;PRKCA;GABRR3;GAD2;GNAI2;GABRD;HAP1 |
| Dopaminergic synapse | PLCB2;DDC;PPP2R3A;CREB3L1;PRKCB;CAMK2G;PPP3CB;KCNJ5;PRKCA |
| Olfactory transduction | OR51B5;OLFR1002;OR1L1;PRKACB;OLFR480;OLFR488;OLFR151;OR5B2;OR4D2 |
| Taste transduction | TAS2R109;GNAT3;TAS2R7;TAS2R120;TAS1R2;TAS2R42;KCNB1;TAS2R106;ALPHA-ENAC |
| Inflammatory mediator regulation of TRP channels | CYP4A10;ACCN3;PPP1CA;HTR2C;PLA2G4F;PLA2G4D;PLCB1;MAPK10;ACCN4 |
| Insulin signaling pathway | RPS6KB2;ACACB;CALML5;PRKAR1B;EXOC7;SREBF1;PRKAR2B;EIF4E2;MAP2K1 |
| Insulin secretion | CAMK2D;GLP1R;ATP1A2;INS1;GNAS;KCNMB3;PRKCB;ATP1B4;CAMK2B |
| GnRH signaling pathway | MMP14B;MAP3K3;MMP14;CAMK2D;CACNA1C;PTK2B;MAP3K4;GNAQ;PLD2 |
| Ovarian steroidogenesis | INS1;PRKACG;HSD17B1;LHCGR;PLA2G4F;HSD17B7;PTGS2;PLA2G4D;INS |
| Progesterone-mediated oocyte maturation | PGR;CPEB4;CDC16;PIK3R1;ARAF;PIK3R2;PRKACB;MAPK1;RAF1A |
| Estrogen signaling pathway | CALML3;CREB3L3;PLCB3;ESR2;PIK3CD;CREB3L1;MMP2;GNAI3;NOS3 |
| Melanogenesis | GNAI3;MITFA;WNT9A;GNAO1;PLCB4;WNT3A;FZD9B;NRAS;TYRP1 |
| Thyroid hormone synthesis | GPX7;LRP2;HSPA5;FXYD2;CREB3L2;GNAS;SLC5A5;GPX8;PLCB1 |
| Thyroid hormone signaling pathway | PIK3R3;NCOR1;ATP1B3;TSC2;KRAS;PIK3R1;MAP2K2;HIF1A;PLCD1 |
| Oxytocin signaling pathway | PLCB4;PRKCG;NPR2;MEF2C;NRAS;CD38;RHOA;GNAI3;CAMK1G |
| Regulation of lipolysis in adipocytes | GNAS;PRKG1;PIK3R1;AQP7;LIPE;PRKACB;INSR;AKT2;INS2 |
| Renin secretion | PRKACB;PPP3CC;GNAS;CLCA2;PDE3A;PTGER4;PPP3CA;GNAI1;CLCA4 |
| Aldosterone synthesis and secretion | ITPR3;CREB3L3;CYP11A1;NR4A1;NETO2;KCNK9;AGTR1B;PLCB2;CAMK4 |
| Endocrine and other factor-regulated calcium reabsorption | ATP1A4;ATP1A3;KL;GNAS;DNM3;PRKACA;PLCB2;PRKACG;PLCB1 |
| Salivary secretion | CALM3;CST3;PRKACA;GNAS;PRKACG;Slc4a2;PRB1;PRH2;ATP1A1 |
| Gastric acid secretion | MYLK;PRKACG;MYLK2;ATP1A1;ATP1B4;KCNK10;KCNJ15;CALM1;GNAS |
| Bile secretion | SLC51B;Car2;OSTA;SCARB1;PRKACB;ABCB1;PRKACA;SLC9A3;NCEH1 |
| Parkinsons disease | ATP5G3;COX7B2;PRKACA;PINK1;NDUFS7;HTRA2;Casp3;ATP5O;NDUFA4L2 |
| Prion diseases | LAMC1;IL6;PRKACB;C6;ELK1;FYN;STIP1;HSPA5;NCAM1 |
| Cocaine addiction | GNAI2;ATF4;RGS9;DRD2;ATF6B;GNAI3;TH;CREB3L1;PRKACB |
| Alcoholism | HIST2H3C2;GNAI2;H3F3C;TH;HIST1H2AF;SLC18A1;MAPK3;HIST1H2BB;HIST1H4I |
| Vibrio cholerae infection | ATP6V1A;ATP6V1B2;ATP6V0A1;SEC61G;KDELR3;ATP6V0A2;PRKCA;PLCG1;ATP6V0A4 |
| Amoebiasis | Itgam&Itgb2;IL6;PIK3R5;AASS;GNAL;COL4A3;LAMB3;IL1B;IL1R1 |
| HTLV-I infection | WNT11;MYBL1;DVL1;Il2;ZFP36;HLA-DMA;WNT2B;VCAM1;CD3E; CD3D |
| Epstein-Barr virus infection | TRAF5;HDAC5;SND1;RBPJL;CDK1;POLR3D;HLA-DRB3;TBK1;CCNA2 |
| Pathways in cancer | PLEKHG5;MSH3;GNAI1;RALBP1;GNG13;GLI1;GNG4;TGFBR1;BMP4 |
| Viral carcinogenesis | NFKBIA;STAT5B;MAD1L1;LTBR;BAD;PIK3CA;CREB3L2;TBPL1;HDAC3 |
| Proteoglycans in cancer | FLNC;NANOG;PLCG1;TFAP4;WNT3;DROSHA;Fasl;CAMK2G;HPSE |
| Dilated cardiomyopathy | TGFB2;MYH7;ADRB1;CACNB4;TNNC1;TPM3;TPM1;PRKACB;CACNA2D2 |
PRKACA has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACA itself. We selected most functions PRKACA had, and list some proteins which have the same functions with PRKACA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | FAM20B;MAP3K10;ATP6V1AA;CDC7;MARS;Acsm2a;ITPK1A;UBE2Q1;KIF5C |
| cAMP-dependent protein kinase activity | PRKAA1;PRKACA;AKAP13;PRKAG1;PRKACB;PRKACG;PRKX |
| protein binding | USP14;CRB3;DYRK1A;GNA12;PTPN11;PGF;XRCC4;IL6;ITGB7 |
| protein complex binding | CPS1;SIX2;CPD;TAPBPL;KAT2B;CRHR1;BRK1;SREBF1;TUB |
| protein kinase A regulatory subunit binding | RYR2;AKAP6;AKAP8;AKAP5;PJA2;ACBD3;PRKACA;EZR;ARFGEF2 |
| protein kinase binding | CD8A;CLTC;EPHA1;CAMK2N1A;HDAC4;BAD;PTEN;MLKL;STAP1 |
| protein serine/threonine/tyrosine kinase activity | DYRK1B;DYRK4;DYRK3;SGK1;DYRK2;CLK3;PRKACA;CLK2;DYRK1A |
| ubiquitin protein ligase binding | GPR19;RANGAP1;SLC22A18;ARIH1;YWHAE;CCT2;PIAS2;NPLOC4;CDKN1A |
PRKACA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACA here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACA.
PRKAR1A; PRKAR2B; GSK3B; PRKAR2A; PRKAR1B; LRRK2
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